InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SDC2

Summary

InnateDB Gene

IDBG-29494.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SDC2

Gene Name

syndecan 2

Synonyms

CD362; HSPG; HSPG1; SYND2

Species

Homo sapiens

Ensembl Gene

ENSG00000169439

Encoded Proteins

IDBP-29496

syndecan 2

IDBP-475015

syndecan 2

IDBP-484699

syndecan 2

IDBP-482442

syndecan 2

IDBP-478508

syndecan 2

IDBP-477937

syndecan 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-2 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-2 expression has been detected in several different tumor types. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:96493351-96611780

Strand

Forward strand

Band

q22.1

Transcripts

ENST00000302190	ENSP00000307046
ENST00000520233
ENST00000519587
ENST00000518385	ENSP00000429045
ENST00000522911	ENSP00000427784
ENST00000519914	ENSP00000428256
ENST00000521590	ENSP00000429121
ENST00000523877	ENSP00000429662

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	32 [view]
Protein-Protein	31 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008092	cytoskeletal protein binding
GO:0030165	PDZ domain binding

Biological Process

GO:0001523	retinoid metabolic process
GO:0001666	response to hypoxia
GO:0005975	carbohydrate metabolic process
GO:0006024	glycosaminoglycan biosynthetic process
GO:0006027	glycosaminoglycan catabolic process
GO:0007603	phototransduction, visible light
GO:0008150	biological_process
GO:0030198	extracellular matrix organization
GO:0030203	glycosaminoglycan metabolic process
GO:0030204	chondroitin sulfate metabolic process
GO:0031000	response to caffeine
GO:0042060	wound healing
GO:0044281	small molecule metabolic process
GO:0048813	dendrite morphogenesis
GO:0048814	regulation of dendrite morphogenesis

Cellular Component

GO:0005796	Golgi lumen
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043025	neuronal cell body
GO:0043202	lysosomal lumen
GO:0045202	synapse

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000022261

View Gene Order

ENSBTAG00000014357

Not yet available

Pathways

NETPATH

NetPath_7

TGF_beta_Receptor pathway

NetPath_10

Hedgehog pathway

REACTOME

REACT_24968

Retinoid metabolism and transport pathway

REACT_121408

A tetrasaccharide linker sequence is required for GAG synthesis pathway

REACT_120752

HS-GAG degradation pathway

REACT_121248

HS-GAG biosynthesis pathway

REACT_111045

Developmental Biology pathway

REACT_147853

Mucopolysaccharidoses pathway

REACT_200783

Myoclonic epilepsy of Lafora pathway

REACT_118779

Extracellular matrix organization pathway

REACT_267711

Defective B4GALT7 causes EDS, progeroid type pathway

REACT_267713

Defective CHST6 causes MCDC1 pathway

REACT_228085

EPHB-mediated forward signaling pathway

REACT_147719

MPS VI - Maroteaux-Lamy syndrome pathway

REACT_267645

Defective PAPSS2 causes SEMD-PA pathway

REACT_474

Metabolism of carbohydrates pathway

REACT_147749

MPS IIID - Sanfilippo syndrome D pathway

REACT_163942

Syndecan interactions pathway

REACT_18266

Axon guidance pathway

REACT_267662

Defective SLC26A2 causes chondrodysplasias pathway

REACT_111102

Signal Transduction pathway

REACT_147739

MPS IX - Natowicz syndrome pathway

REACT_267674

Defective EXT1 causes exostoses 1, TRPS2 and CHDS pathway

REACT_267642

Defective CHST14 causes EDS, musculocontractural type pathway

REACT_121314

Heparan sulfate/heparin (HS-GAG) metabolism pathway

REACT_160102

Diseases associated with visual transduction pathway

REACT_147798

MPS IV - Morquio syndrome B pathway

REACT_267659

Defective B3GAT3 causes JDSSDHD pathway

REACT_163874

Non-integrin membrane-ECM interactions pathway

REACT_267708

Defective CHST3 causes SEDCJD pathway

REACT_147825

MPS IV - Morquio syndrome A pathway

REACT_267654

Defective EXT2 causes exostoses 2 pathway

REACT_267707

Diseases associated with glycosaminoglycan metabolism pathway

REACT_147734

MPS II - Hunter syndrome pathway

REACT_267635

Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) pathway

REACT_160125

Visual phototransduction pathway

REACT_121315

Glycosaminoglycan metabolism pathway

REACT_267705

Diseases of glycosylation pathway

REACT_121206

Chondroitin sulfate/dermatan sulfate metabolism pathway

REACT_147759

MPS VII - Sly syndrome pathway

REACT_228170

EPH-Ephrin signaling pathway

REACT_267682

Defective CHSY1 causes TPBS pathway

REACT_111217

Metabolism pathway

REACT_147857

MPS I - Hurler syndrome pathway

REACT_147753

MPS IIIA - Sanfilippo syndrome A pathway

REACT_147860

MPS IIIC - Sanfilippo syndrome C pathway

REACT_116125

Disease pathway

REACT_200833

Glycogen storage diseases pathway

REACT_147788

MPS IIIB - Sanfilippo syndrome B pathway

KEGG

hsa04514

Cell adhesion molecules (CAMs) pathway

hsa05144

Malaria pathway

INOH

INOH website

Integrin signaling pathway pathway

INOH website

Wnt signaling pathway pathway

PID NCI

syndecan_2_pathway

Syndecan-2-mediated signaling events

syndecan_pathway

Proteoglycan syndecan-mediated signaling events

fgf_pathway

FGF signaling pathway

shp2_pathway

SHP2 signaling

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.1501 Hs.595421 Hs.598247 Hs.611517 Hs.739202

RefSeq

NM_002998 XM_005251019 XM_006716614

HUGO

OMIM

CCDS

CCDS6272

HPRD

00803

IMGT

EMBL

GenPept

RNA Seq Atlas