Version 5.4
Homo sapiens Gene: PEX11A
Summary
InnateDB Gene IDBG-29520.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PEX11A
Gene Name peroxisomal biogenesis factor 11 alpha
Synonyms hsPEX11p; PEX11-ALPHA; PMP28
Species Homo sapiens
Ensembl Gene ENSG00000166821
Encoded Proteins
IDBP-29522
peroxisomal biogenesis factor 11 alpha
IDBP-597529
peroxisomal biogenesis factor 11 alpha
IDBP-593623
peroxisomal biogenesis factor 11 alpha
IDBP-596064
peroxisomal biogenesis factor 11 alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the PEX11 family, which is composed of membrane elongation factors involved in regulation of peroxisome maintenance and proliferation. This gene product interacts with peroxisomal membrane protein 19 and may respond to outside stimuli to increase peroxisome abundance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:89677764-89690783
Strand Reverse strand
Band q26.1
Transcripts
ENST00000300056 ENSP00000300056
ENST00000557982
ENST00000561224 ENSP00000453552
ENST00000561257 ENSP00000453492
ENST00000559170 ENSP00000453878
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0007031 peroxisome organization
GO:0007165 signal transduction
GO:0016557 peroxisome membrane biogenesis
GO:0016559 peroxisome fission
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
GO:0044375 regulation of peroxisome size
GO:0050873 brown fat cell differentiation
Cellular Component
GO:0005777 peroxisome
GO:0005778 peroxisomal membrane
GO:0005779 integral component of peroxisomal membrane
GO:0043234 protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030545
View Gene Order
ENSBTAG00000006140
Not yet available
Pathways
NETPATH
REACTOME
REACT_116145
PPARA activates gene expression pathway
REACT_19241
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_22279
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_111217
Metabolism pathway
KEGG
hsa04146
Peroxisome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL H0YMC7
UniProt Splice Variant
Entrez Gene 8800
UniGene Hs.31034 Hs.736519
RefSeq NM_001271572 NM_001271573 NM_003847
HUGO HGNC:8852
OMIM 603866
CCDS CCDS10354 CCDS61751
HPRD 04843
IMGT
EMBL AC013787
GenPept
RNA Seq Atlas 8800

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca