Version 5.4
| Homo sapiens Gene: CYP3A43 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-29806.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | CYP3A43 | ||||||||||||||||||
| Gene Name | cytochrome P450, family 3, subfamily A, polypeptide 43 | ||||||||||||||||||
| Synonyms | |||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000021461 | ||||||||||||||||||
| Encoded Proteins |
cytochrome P450, family 3, subfamily A, polypeptide 43
cytochrome P450, family 3, subfamily A, polypeptide 43
cytochrome P450, family 3, subfamily A, polypeptide 43
cytochrome P450, family 3, subfamily A, polypeptide 43
cytochrome P450, family 3, subfamily A, polypeptide 43
cytochrome P450, family 3, subfamily A, polypeptide 43
cytochrome P450, family 3, subfamily A, polypeptide 43
cytochrome P450, family 3, subfamily A, polypeptide 43
cytochrome P450, family 3, subfamily A, polypeptide 43
cytochrome P450, family 3, subfamily A, polypeptide 43
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| Protein Structure | |||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme has a low level of testosterone hydroxylase activity. Although it bears homology to some drug-metabolizing cytochrome P450s, it is unknown whether the enzyme is also involved in xenobiotic metabolism. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Alternate splicing of this gene results in three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 7:99828013-99866102 | ||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||
| Band | q22.1 | ||||||||||||||||||
| Transcripts | |||||||||||||||||||
| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
| No orthologs found for this gene | |||||||||||||||||||
| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
Miscellaneous substrates pathway
Xenobiotics pathway
Cytochrome P450 - arranged by substrate type pathway
Metabolism pathway
Biological oxidations pathway
Phase 1 - Functionalization of compounds pathway
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| KEGG | |||||||||||||||||||
| INOH |
Tryptophan degradation pathway
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| PID NCI | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | |||||||||||||||||||
| TrEMBL | |||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| UniGene | Hs.306220 | ||||||||||||||||||
| RefSeq | NM_001278921 NM_022820 NM_057095 NM_057096 | ||||||||||||||||||
| HUGO | |||||||||||||||||||
| OMIM | |||||||||||||||||||
| CCDS | CCDS5675 CCDS5676 CCDS5677 CCDS64723 | ||||||||||||||||||
| HPRD | 05942 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | |||||||||||||||||||
| GenPept | |||||||||||||||||||
| RNA Seq Atlas | |||||||||||||||||||