Version 5.4
Homo sapiens Protein: CYP3A43
Summary
InnateDB Protein IDBP-29808.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CYP3A43
Protein Name cytochrome P450, family 3, subfamily A, polypeptide 43
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000222382
InnateDB Gene IDBG-29806 (CYP3A43)
Protein Structure
UniProt Annotation
Function Exhibits low testosterone 6-beta-hydroxylase activity.
Subcellular Localization Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Disease Associations
Tissue Specificity Highest expression level in prostate. Also expressed in liver, kidney, pancreas, fetal liver and fetal skeletal muscle. {ECO:0000269PubMed:11160876, ECO:0000269PubMed:11243885}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 0
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding
GO:0070330 aromatase activity
Biological Process
GO:0006805 xenobiotic metabolic process
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
Protein Structure and Domains
PDB ID
InterPro IPR001128 Cytochrome P450
IPR002401 Cytochrome P450, E-class, group I
IPR002402 Cytochrome P450, E-class, group II
IPR002403 Cytochrome P450, E-class, group IV
IPR008072 Cytochrome P450, E-class, CYP3A
PFAM PF00067
PRINTS PR00385
PR00463
PR00464
PR00465
PR01689
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9HB55
PhosphoSite PhosphoSite-Q9HB55
TrEMBL Q7Z2G5
UniProt Splice Variant
Entrez Gene 64816
UniGene Hs.306220
RefSeq NP_073731
HUGO HGNC:17450
OMIM 606534
CCDS CCDS5675
HPRD 05942
IMGT
EMBL AC011904 AF280107 AF280108 AF280109 AF280110 AF280111 AF319634 AF337813 AJ563376 AJ563378 AJ563379 AY390423 AY390424 AY390425 AY390426 CH471091
GenPept AAG32291 AAG33009 AAG33010 AAG33011 AAG33012 AAK00325 AAK38841 AAQ92351 AAQ92352 AAQ92353 AAQ92354 AAS07394 CAD91644 CAD91646 CAD91648 EAW76634

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca