Version 5.4
| Homo sapiens Gene: CLDN14 | |||||||||||||
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| Summary | |||||||||||||
| InnateDB Gene | IDBG-2998.6 | ||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||
| Gene Symbol | CLDN14 | ||||||||||||
| Gene Name | claudin 14 | ||||||||||||
| Synonyms | DFNB29 | ||||||||||||
| Species | Homo sapiens | ||||||||||||
| Ensembl Gene | ENSG00000159261 | ||||||||||||
| Encoded Proteins |
claudin 14
claudin 14
claudin 14
claudin 14
claudin 14
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| Protein Structure | |||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||
| Entrez Gene | |||||||||||||
| Summary |
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. The encoded protein also binds specifically to the WW domain of Yes-associated protein. Defects in this gene are the cause of an autosomal recessive form of nonsyndromic sensorineural deafness. It is also reported that four synonymous variants in this gene are associated with kidney stones and reduced bone mineral density. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2010] |
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| Gene Information | |||||||||||||
| Type | Protein coding | ||||||||||||
| Genomic Location | Chromosome 21:36460621-36576569 | ||||||||||||
| Strand | Reverse strand | ||||||||||||
| Band | q22.13 | ||||||||||||
| Transcripts |
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| Interactions | |||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||
| NETPATH | |||||||||||||
| REACTOME |
Tight junction interactions pathway
Cell-Cell communication pathway
Cell junction organization pathway
Cell-cell junction organization pathway
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| KEGG |
Cell adhesion molecules (CAMs) pathway
Leukocyte transendothelial migration pathway
Tight junction pathway
Hepatitis C pathway
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| INOH | |||||||||||||
| PID NCI | |||||||||||||
| Cross-References | |||||||||||||
| SwissProt | |||||||||||||
| TrEMBL | |||||||||||||
| UniProt Splice Variant | |||||||||||||
| Entrez Gene | |||||||||||||
| UniGene | Hs.660278 Hs.741857 | ||||||||||||
| RefSeq | NM_001146077 NM_001146078 NM_001146079 NM_012130 NM_144492 | ||||||||||||
| HUGO | |||||||||||||
| OMIM | |||||||||||||
| CCDS | CCDS13645 | ||||||||||||
| HPRD | 05727 | ||||||||||||
| IMGT | |||||||||||||
| EMBL | |||||||||||||
| GenPept | |||||||||||||
| RNA Seq Atlas | |||||||||||||