InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: CLDN14

Summary

InnateDB Gene

IDBG-647360.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CLDN14

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000030585

Encoded Proteins

IDBP-700194

claudin 14

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000159261:
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. The encoded protein also binds specifically to the WW domain of Yes-associated protein. Defects in this gene are the cause of an autosomal recessive form of nonsyndromic sensorineural deafness. It is also reported that four synonymous variants in this gene are associated with kidney stones and reduced bone mineral density. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:150439867-150440580

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000043204

ENSBTAP00000040792

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005198	structural molecule activity
GO:0005515	protein binding

Biological Process

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005886	plasma membrane
GO:0005923	tight junction
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction