Version 5.4
Homo sapiens Gene: TAS2R46
Summary
InnateDB Gene IDBG-300601.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TAS2R46
Gene Name taste receptor, type 2, member 46
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000226761
Encoded Proteins
IDBP-597557
taste receptor, type 2, member 46
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary TAS2R46 belongs to the large TAS2R receptor family. TAS2Rs are expressed on the surface of taste receptor cells and mediate the perception of bitterness through a G protein-coupled second messenger pathway (Conte et al., 2002 [PubMed 12584440]). For further information on TAS2Rs, see MIM 604791.[supplied by OMIM, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:11061365-11062294
Strand Reverse strand
Band p13.2
Transcripts
ENST00000533467 ENSP00000436450
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0033038 bitter taste receptor activity
Biological Process
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste
GO:0007186 G-protein coupled receptor signaling pathway
GO:0050909 sensory perception of taste
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0060170 ciliary membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_19231
G alpha (i) signalling events pathway
REACT_18319
Class C/3 (Metabotropic glutamate/pheromone receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21340
GPCR ligand binding pathway
KEGG
hsa04742
Taste transduction pathway
INOH
PID NCI
Cross-References
SwissProt P59540
TrEMBL Q50KH0
UniProt Splice Variant
Entrez Gene 259292
UniGene Hs.688193
RefSeq NM_176887
HUGO HGNC:18877
OMIM 612774
CCDS CCDS53748
HPRD 18155
IMGT
EMBL AB199205 AF494227 AY114091 AY724941
GenPept AAM19318 AAM63541 AAU21143 BAD98078
RNA Seq Atlas 259292

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca