InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TAS2R46

Summary

InnateDB Protein

IDBP-597557.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TAS2R46

Protein Name

taste receptor, type 2, member 46

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000436450

InnateDB Gene

IDBG-300601 (TAS2R46)

Protein Structure

UniProt Annotation

Function

Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). In airway epithelial cells, binding of bitter compounds increases the intracellular calcium ion concentration and stimulates ciliary beat frequency (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000269PubMed:19628819}; Multi-pass membrane protein {ECO:0000269PubMed:19628819}. Cell projection, cilium membrane {ECO:0000269PubMed:19628819}. Note=In airway epithelial cells, localizes to motile cilia.

Disease Associations

Tissue Specificity

Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells. Expressed on ciliated airway epithelium. {ECO:0000269PubMed:19628819}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0033038	bitter taste receptor activity

Biological Process

GO:0001580	detection of chemical stimulus involved in sensory perception of bitter taste
GO:0007186	G-protein coupled receptor signaling pathway
GO:0050909	sensory perception of taste