Version 5.4
Homo sapiens Gene: COX6C
Summary
InnateDB Gene IDBG-30459.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol COX6C
Gene Name cytochrome c oxidase subunit VIc
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000164919
Encoded Proteins
IDBP-30461
cytochrome c oxidase subunit VIc
IDBP-482773
cytochrome c oxidase subunit VIc
IDBP-482028
cytochrome c oxidase subunit VIc
IDBP-481668
cytochrome c oxidase subunit VIc
IDBP-477503
cytochrome c oxidase subunit VIc
IDBP-484089
cytochrome c oxidase subunit VIc
IDBP-473480
cytochrome c oxidase subunit VIc
IDBP-476379
cytochrome c oxidase subunit VIc
IDBP-483735
cytochrome c oxidase subunit VIc
IDBP-480548
cytochrome c oxidase subunit VIc
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes subunit VIc, which has 77% amino acid sequence identity with mouse subunit VIc. This gene is up-regulated in prostate cancer cells. A pseudogene has been found on chromosomes 16p12. [provided by RefSeq, Jul 2010]
Cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes subunit VIc, which has 77%% amino acid sequence identity with mouse subunit VIc. This gene is up-regulated in prostate cancer cells. A pseudogene has been found on chromosomes 16p12. [provided by RefSeq, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:99873200-99894062
Strand Reverse strand
Band q22.2
Transcripts
ENST00000297564 ENSP00000297564
ENST00000522934 ENSP00000428702
ENST00000520517 ENSP00000429991
ENST00000520468 ENSP00000428895
ENST00000520271 ENSP00000428150
ENST00000517682 ENSP00000429714
ENST00000524245 ENSP00000429410
ENST00000522940 ENSP00000428965
ENST00000518171 ENSP00000429755
ENST00000523016 ENSP00000429707
ENST00000606245
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 6 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004129 cytochrome-c oxidase activity
Biological Process
GO:0006091 generation of precursor metabolites and energy
GO:0022904 respiratory electron transport chain
GO:0044237 cellular metabolic process
GO:0044281 small molecule metabolic process
GO:1902600 hydrogen ion transmembrane transport
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000014313
View Gene Order
ENSBTAG00000014130
Not yet available
Pathways
NETPATH
REACTOME
REACT_22393
Respiratory electron transport pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_6305
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. pathway
REACT_267716
Orphan transporters pathway
REACT_111083
The citric acid (TCA) cycle and respiratory electron transport pathway
REACT_111217
Metabolism pathway
KEGG
hsa05010
Alzheimer's disease pathway
hsa00190
Oxidative phosphorylation pathway
hsa05012
Parkinson's disease pathway
hsa05016
Huntington's disease pathway
hsa04260
Cardiac muscle contraction pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_004374
HUGO
OMIM
CCDS CCDS6284
HPRD 00494
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca