Version 5.4
Homo sapiens Gene: FBXO43
Summary
InnateDB Gene IDBG-30514.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FBXO43
Gene Name F-box protein 43
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000156509
Encoded Proteins
IDBP-374398
F-box protein 43
IDBP-475068
F-box protein 43
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Members of the F-box protein family, such as FBXO43, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:100133360-100145800
Strand Reverse strand
Band q22.2
Transcripts
ENST00000428847 ENSP00000403293
ENST00000517806 ENSP00000429759
ENST00000520987
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
Biological Process
GO:0007126 meiotic nuclear division
GO:0016567 protein ubiquitination
GO:0040020 regulation of meiosis
GO:0042177 negative regulation of protein catabolic process
GO:0045835 negative regulation of meiosis
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000048230
View Gene Order
ENSBTAG00000019795
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04114
Oocyte meiosis pathway
INOH
PID NCI
Cross-References
SwissProt Q4G163
TrEMBL E5RHI5
UniProt Splice Variant
Entrez Gene 286151
UniGene Hs.339577
RefSeq NM_001029860
HUGO HGNC:28521
OMIM 609110
CCDS CCDS47904
HPRD
IMGT
EMBL AC021590
GenPept
RNA Seq Atlas 286151

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca