Version 5.4
Homo sapiens Gene: ACIN1
Summary
InnateDB Gene IDBG-3055.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ACIN1
Gene Name apoptotic chromatin condensation inducer 1
Synonyms ACINUS; ACN; fSAP152
Species Homo sapiens
Ensembl Gene ENSG00000100813
Encoded Proteins
IDBP-3057
apoptotic chromatin condensation inducer 1
IDBP-3059
apoptotic chromatin condensation inducer 1
IDBP-3061
apoptotic chromatin condensation inducer 1
IDBP-235563
apoptotic chromatin condensation inducer 1
IDBP-361982
apoptotic chromatin condensation inducer 1
IDBP-807296
apoptotic chromatin condensation inducer 1
IDBP-584400
apoptotic chromatin condensation inducer 1
IDBP-585120
apoptotic chromatin condensation inducer 1
IDBP-583407
apoptotic chromatin condensation inducer 1
IDBP-807323
apoptotic chromatin condensation inducer 1
IDBP-807311
apoptotic chromatin condensation inducer 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Apoptosis is defined by several morphologic nuclear changes, including chromatin condensation and nuclear fragmentation. This gene encodes a nuclear protein that induces apoptotic chromatin condensation after activation by caspase-3, without inducing DNA fragmentation. This protein has also been shown to be a component of a splicing-dependent multiprotein exon junction complex (EJC) that is deposited at splice junctions on mRNAs, as a consequence of pre-mRNA splicing. It may thus be involved in mRNA metabolism associated with splicing. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:23058564-23095614
Strand Reverse strand
Band q11.2
Transcripts
ENST00000262710 ENSP00000262710
ENST00000338631 ENSP00000345541
ENST00000357481 ENSP00000350073
ENST00000397341 ENSP00000380502
ENST00000457657 ENSP00000405677
ENST00000473758 ENSP00000483298
ENST00000557515 ENSP00000451138
ENST00000555053 ENSP00000451328
ENST00000555478
ENST00000555395
ENST00000554680
ENST00000553790
ENST00000556052
ENST00000555566 ENSP00000451410
ENST00000557039
ENST00000555807
ENST00000553721
ENST00000557432
ENST00000555352 ENSP00000481955
ENST00000553501
ENST00000554979
ENST00000554708
ENST00000605057 ENSP00000474349
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 93 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 93 [view]
Protein-Protein 92 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0005515 protein binding
GO:0016887 ATPase activity
GO:0019899 enzyme binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006200 ATP catabolic process
GO:0006397 mRNA processing
GO:0006915 apoptotic process
GO:0006921 cellular component disassembly involved in execution phase of apoptosis
GO:0008380 RNA splicing
GO:0030218 erythrocyte differentiation
GO:0030263 apoptotic chromosome condensation
GO:0043065 positive regulation of apoptotic process
GO:0045657 positive regulation of monocyte differentiation
GO:0048025 negative regulation of mRNA splicing, via spliceosome
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016607 nuclear speck
GO:0035145 exon-exon junction complex
GO:0061574 ASAP complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022185
View Gene Order
ENSBTAG00000011571
Not yet available
Pathways
NETPATH
REACTOME
REACT_107
Apoptotic cleavage of cellular proteins pathway
REACT_995
Apoptotic execution phase pathway
REACT_578
Apoptosis pathway
KEGG
hsa03040
Spliceosome pathway
hsa03013
RNA transport pathway
hsa03015
mRNA surveillance pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL S4R3H4
UniProt Splice Variant
Entrez Gene 22985
UniGene
RefSeq NM_001164814 NM_001164815 NM_001164816 NM_001164817 NM_014977 XM_005267415 XM_005267416 XM_005267418
HUGO HGNC:17066
OMIM 604562
CCDS CCDS53887 CCDS53888 CCDS53889 CCDS55905 CCDS9587
HPRD
IMGT
EMBL AL117258 AL132780
GenPept
RNA Seq Atlas 22985

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca