Version 5.4
Mus musculus Gene: Acin1
Summary
InnateDB Gene IDBG-161881.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Acin1
Gene Name apoptotic chromatin condensation inducer 1
Synonyms 2610036I19Rik; 2610510L13Rik; Acinus; acinusL; acinusS; Acn; C79325; mKIAA0670
Species Mus musculus
Ensembl Gene ENSMUSG00000022185
Encoded Proteins
IDBP-161883
apoptotic chromatin condensation inducer 1
IDBP-161885
apoptotic chromatin condensation inducer 1
IDBP-258006
apoptotic chromatin condensation inducer 1
IDBP-542039
apoptotic chromatin condensation inducer 1
IDBP-541373
apoptotic chromatin condensation inducer 1
IDBP-539093
apoptotic chromatin condensation inducer 1
IDBP-538534
apoptotic chromatin condensation inducer 1
IDBP-541137
apoptotic chromatin condensation inducer 1
IDBP-540553
apoptotic chromatin condensation inducer 1
IDBP-541864
apoptotic chromatin condensation inducer 1
IDBP-542056
apoptotic chromatin condensation inducer 1
IDBP-620199
apoptotic chromatin condensation inducer 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100813:
Apoptosis is defined by several morphologic nuclear changes, including chromatin condensation and nuclear fragmentation. This gene encodes a nuclear protein that induces apoptotic chromatin condensation after activation by caspase-3, without inducing DNA fragmentation. This protein has also been shown to be a component of a splicing-dependent multiprotein exon junction complex (EJC) that is deposited at splice junctions on mRNAs, as a consequence of pre-mRNA splicing. It may thus be involved in mRNA metabolism associated with splicing. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:54642161-54686931
Strand Reverse strand
Band C2
Transcripts
ENSMUST00000022793 ENSMUSP00000022793
ENSMUST00000022794 ENSMUSP00000022794
ENSMUST00000111484 ENSMUSP00000107109
ENSMUST00000141453 ENSMUSP00000116664
ENSMUST00000126166 ENSMUSP00000114546
ENSMUST00000147714 ENSMUSP00000119080
ENSMUST00000150371 ENSMUSP00000118069
ENSMUST00000148754 ENSMUSP00000122003
ENSMUST00000152773
ENSMUST00000138321 ENSMUSP00000119326
ENSMUST00000151487
ENSMUST00000124271
ENSMUST00000133706
ENSMUST00000125767
ENSMUST00000123875 ENSMUSP00000117210
ENSMUST00000136909
ENSMUST00000137763
ENSMUST00000149713
ENSMUST00000129700
ENSMUST00000141993
ENSMUST00000125265 ENSMUSP00000120445
ENSMUST00000134808
ENSMUST00000132242
ENSMUST00000167015 ENSMUSP00000125776
ENSMUST00000167495
ENSMUST00000170299
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 65 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 65 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006397 mRNA processing
GO:0006915 apoptotic process
GO:0008380 RNA splicing
GO:0030218 erythrocyte differentiation
GO:0030263 apoptotic chromosome condensation
GO:0043065 positive regulation of apoptotic process
GO:0045657 positive regulation of monocyte differentiation
GO:0048025 negative regulation of mRNA splicing, via spliceosome
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016607 nuclear speck
GO:0035145 exon-exon junction complex
GO:0061574 ASAP complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000100813
View Gene Order
ENSBTAG00000011571
Not yet available
Pathways
NETPATH
REACTOME
REACT_258521
Apoptosis pathway
REACT_224460
Apoptotic cleavage of cellular proteins pathway
REACT_207035
Apoptotic execution phase pathway
KEGG
mmu03040
Spliceosome pathway
mmu03013
RNA transport pathway
mmu03015
mRNA surveillance pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_107
Apoptotic cleavage of cellular proteins pathway
REACT_995
Apoptotic execution phase pathway
REACT_578
Apoptosis pathway
KEGG
hsa03040
Spliceosome pathway
hsa03013
RNA transport pathway
hsa03015
mRNA surveillance pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 56215
UniGene Mm.297078
RefSeq NM_001085472 NM_001085473 NM_001242605 NM_001242606 NM_019567 NM_023190 XM_006519296 XM_006519297 XM_006519298 XM_006519301 XM_006519302 XM_006519303 XM_006519304 XM_006519305 XM_006519306 XM_006519307 XM_006519308
OMIM
CCDS CCDS27097 CCDS27098 CCDS49492 CCDS56956 CCDS56957
HPRD
IMGT
MGI ID MGI:1891824
MGI Symbol Acin1
EMBL
GenPept
RNA Seq Atlas 56215

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca