Version 5.4
Homo sapiens Gene: NFAM1
Summary
InnateDB Gene IDBG-305628.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NFAM1
Gene Name NFAT activating protein with ITAM motif 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000235568
Encoded Proteins
IDBP-9951
NFAT activating protein with ITAM motif 1
IDBP-9953
NFAT activating protein with ITAM motif 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a type I membrane receptor that activates cytokine gene promoters such as the IL-13 and TNF-alpha promoters. The encoded protein contains an immunoreceptor tyrosine-based activation motif (ITAM) and is thought to regulate the signaling and development of B-cells. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:42380410-42432395
Strand Reverse strand
Band q13.2
Transcripts
ENST00000355469 ENSP00000347650
ENST00000329021 ENSP00000333680
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
Biological Process
GO:0001819 positive regulation of cytokine production
GO:0006954 inflammatory response
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0030183 B cell differentiation
GO:0035556 intracellular signal transduction
GO:0045577 regulation of B cell differentiation
GO:0050853 B cell receptor signaling pathway
GO:0050861 positive regulation of B cell receptor signaling pathway
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
Cellular Component
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0045121 membrane raft
Orthologs
No orthologs found for this gene
Pathways
NETPATH
NetPath_11
TCR pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.436677
RefSeq NM_145912 XM_005261374
HUGO
OMIM
CCDS CCDS14034
HPRD 16380
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca