Version 5.4
Homo sapiens Protein: NFAM1
Summary
InnateDB Protein IDBP-9953.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NFAM1
Protein Name NFAT activating protein with ITAM motif 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000333680
InnateDB Gene IDBG-305628 (NFAM1)
Protein Structure
UniProt Annotation
Function May function in immune system as a receptor which activates via the calcineurin/NFAT-signaling pathway the downstream cytokine gene promoters. Activates the transcription of IL-13 and TNF-alpha promoters. May be involved in the regulation of B-cell, but not T-cell, development. Overexpression activates downstream effectors without ligand binding or antibody cross- linking. {ECO:0000269PubMed:12615919, ECO:0000269PubMed:15143214}.
Subcellular Localization Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Partially recruited to lipid rafts upon BCR stimulation. {ECO:0000250}.
Disease Associations
Tissue Specificity Highly expressed in neutrophils, primary monocytes, mast cells, monocytic cell lines and lymphocytes. Also expressed in spleen B and T-cells, and lung. Expressed at low level in non-immune tissue. {ECO:0000269PubMed:12615919, ECO:0000269PubMed:15143214}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
Biological Process
GO:0001819 positive regulation of cytokine production
GO:0006954 inflammatory response
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007242 intracellular signaling cascade
GO:0030183 B cell differentiation
GO:0035556 intracellular signal transduction
GO:0045577 regulation of B cell differentiation
GO:0050853 B cell receptor signaling pathway
GO:0050861 positive regulation of B cell receptor signaling pathway
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
Cellular Component
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0045121 membrane raft
Protein Structure and Domains
PDB ID
InterPro IPR003110 Phosphorylated immunoreceptor signalling ITAM
PFAM PF02189
PRINTS
PIRSF
SMART SM00077
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8NET5
PhosphoSite PhosphoSite-Q8NET5
TrEMBL
UniProt Splice Variant
Entrez Gene 150372
UniGene Hs.436677
RefSeq NP_666017
HUGO HGNC:29872
OMIM 608740
CCDS CCDS14034
HPRD 16380
IMGT
EMBL AK074094 AL022316 AY121370 AY247409 BC038241 CH471095 CT841509
GenPept AAH38241 AAM83133 AAO91847 BAB84920 CAJ86439 CAQ10428 EAW60505

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca