Version 5.4
Homo sapiens Gene: FKBP11
Summary
InnateDB Gene IDBG-30614.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FKBP11
Gene Name FK506 binding protein 11, 19 kDa
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000134285
Encoded Proteins
IDBP-30616
FK506 binding protein 11, 19 kDa
IDBP-374037
FK506 binding protein 11, 19 kDa
IDBP-374038
FK506 binding protein 11, 19 kDa
IDBP-599711
FK506 binding protein 11, 19 kDa
IDBP-591539
FK506 binding protein 11, 19 kDa
IDBP-601076
FK506 binding protein 11, 19 kDa
IDBP-601500
FK506 binding protein 11, 19 kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary FKBP11 belongs to the FKBP family of peptidyl-prolyl cis/trans isomerases, which catalyze the folding of proline-containing polypeptides. The peptidyl-prolyl isomerase activity of FKBP proteins is inhibited by the immunosuppressant compounds FK506 and rapamycin (Rulten et al., 2006 [PubMed 16596453]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:48921518-48926474
Strand Reverse strand
Band q13.12
Transcripts
ENST00000256680 ENSP00000256680
ENST00000444214 ENSP00000412403
ENST00000453172 ENSP00000396874
ENST00000553027
ENST00000551094
ENST00000550765 ENSP00000449751
ENST00000546847 ENSP00000447411
ENST00000551694
ENST00000552878 ENSP00000447911
ENST00000546671
ENST00000547789 ENSP00000448805
ENST00000549084
ENST00000551807
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003755 peptidyl-prolyl cis-trans isomerase activity
GO:0005528 FK506 binding
Biological Process
GO:0000413 protein peptidyl-prolyl isomerization
GO:0006457 protein folding
GO:0061077 chaperone-mediated protein folding
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000003355
View Gene Order
ENSBTAG00000015828
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.655103
RefSeq NM_001143781 NM_001143782 NM_016594
HUGO
OMIM
CCDS CCDS44870 CCDS44871 CCDS8773
HPRD 11170
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca