Version 5.4
Homo sapiens Gene: WDR83
Summary
InnateDB Gene IDBG-30630.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol WDR83
Gene Name WD repeat domain 83
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000123154
Encoded Proteins
IDBP-372902
WD repeat domain 83
IDBP-372951
WD repeat domain 83
IDBP-602301
WD repeat domain 83
IDBP-585847
WD repeat domain 83
IDBP-589250
WD repeat domain 83
IDBP-597379
WD repeat domain 83
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the WD-40 protein family. The protein is proposed to function as a molecular scaffold for various multimeric protein complexes. The protein associates with several components of the extracellular signal-regulated kinase (ERK) pathway, and promotes ERK activity in response to serum or other signals. The protein also interacts with egl nine homolog 3 (EGLN3, also known as PHD3) and regulates expression of hypoxia-inducible factor 1, and has been purified as part of the spliceosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:12666800-12675832
Strand Forward strand
Band p13.13
Transcripts
ENST00000418543 ENSP00000402653
ENST00000425834 ENSP00000396530
ENST00000546754
ENST00000548381 ENSP00000448722
ENST00000553179 ENSP00000450416
ENST00000547255
ENST00000547481 ENSP00000448331
ENST00000550939
ENST00000551329
ENST00000547797 ENSP00000449257
ENST00000552700
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 51 experimentally validated interaction(s) in this database.
Experimentally validated
Total 51 [view]
Protein-Protein 50 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0016301 kinase activity
Biological Process
GO:0000375 RNA splicing, via transesterification reactions
GO:0000398 mRNA splicing, via spliceosome
GO:0016310 phosphorylation
Cellular Component
GO:0005681 spliceosomal complex
GO:0005737 cytoplasm
GO:0071013 catalytic step 2 spliceosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000005150
View Gene Order
ENSBTAG00000006245
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.657204 Hs.739020
RefSeq NM_001099737 NM_032332
HUGO
OMIM
CCDS CCDS12275
HPRD 14730
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca