Version 5.4
Homo sapiens Gene: PRKAG1
Summary
InnateDB Gene IDBG-30803.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRKAG1
Gene Name protein kinase, AMP-activated, gamma 1 non-catalytic subunit
Synonyms AMPKG
Species Homo sapiens
Ensembl Gene ENSG00000181929
Encoded Proteins
IDBP-30805
protein kinase, AMP-activated, gamma 1 non-catalytic subunit
IDBP-600795
protein kinase, AMP-activated, gamma 1 non-catalytic subunit
IDBP-598061
protein kinase, AMP-activated, gamma 1 non-catalytic subunit
IDBP-601477
protein kinase, AMP-activated, gamma 1 non-catalytic subunit
IDBP-591301
protein kinase, AMP-activated, gamma 1 non-catalytic subunit
IDBP-598673
protein kinase, AMP-activated, gamma 1 non-catalytic subunit
IDBP-592520
protein kinase, AMP-activated, gamma 1 non-catalytic subunit
IDBP-587865
protein kinase, AMP-activated, gamma 1 non-catalytic subunit
IDBP-590372
protein kinase, AMP-activated, gamma 1 non-catalytic subunit
IDBP-586390
protein kinase, AMP-activated, gamma 1 non-catalytic subunit
IDBP-600303
protein kinase, AMP-activated, gamma 1 non-catalytic subunit
IDBP-599276
protein kinase, AMP-activated, gamma 1 non-catalytic subunit
IDBP-596452
protein kinase, AMP-activated, gamma 1 non-catalytic subunit
IDBP-583960
protein kinase, AMP-activated, gamma 1 non-catalytic subunit
IDBP-601874
protein kinase, AMP-activated, gamma 1 non-catalytic subunit
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:49002274-49019197
Strand Reverse strand
Band q13.12
Transcripts
ENST00000316299 ENSP00000323867
ENST00000548362 ENSP00000446987
ENST00000547306 ENSP00000448873
ENST00000548065 ENSP00000447433
ENST00000546531 ENSP00000447637
ENST00000552212 ENSP00000448972
ENST00000551770 ENSP00000449121
ENST00000551696 ENSP00000447671
ENST00000550125
ENST00000552793
ENST00000548950 ENSP00000450112
ENST00000549726
ENST00000551121 ENSP00000449637
ENST00000550448
ENST00000552463 ENSP00000448251
ENST00000548857 ENSP00000448739
ENST00000548605 ENSP00000449104
ENST00000547082 ENSP00000448290
ENST00000547125 ENSP00000450273
ENST00000552657
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 28 [view]
Protein-Protein 27 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004679 AMP-activated protein kinase activity
GO:0004691 cAMP-dependent protein kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008603 cAMP-dependent protein kinase regulator activity
GO:0016208 AMP binding
GO:0019901 protein kinase binding
GO:0030554 adenyl nucleotide binding
GO:0043531 ADP binding
Biological Process
GO:0006110 regulation of glycolytic process
GO:0006468 protein phosphorylation
GO:0006633 fatty acid biosynthetic process
GO:0007050 cell cycle arrest
GO:0007165 signal transduction
GO:0007283 spermatogenesis
GO:0008286 insulin receptor signaling pathway
GO:0010628 positive regulation of gene expression
GO:0045860 positive regulation of protein kinase activity
GO:0050790 regulation of catalytic activity
GO:0051291 protein heterooligomerization
GO:0061024 membrane organization
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
GO:0016020 membrane
GO:0031588 AMP-activated protein kinase complex
GO:0043234 protein complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000067713
View Gene Order
ENSBTAG00000014426
Not yet available
Pathways
NETPATH
REACTOME
REACT_21393
Regulation of Rheb GTPase activity by AMPK pathway
REACT_21285
Regulation of AMPK activity via LKB1 pathway
REACT_6838
mTOR signalling pathway
REACT_976
PI3K Cascade pathway
REACT_498
Signaling by Insulin receptor pathway
REACT_150203
IRS-related events triggered by IGF1R pathway
REACT_150359
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
REACT_147867
Translocation of GLUT4 to the plasma membrane pathway
REACT_21387
Energy dependent regulation of mTOR by LKB1-AMPK pathway
REACT_200751
Organelle biogenesis and maintenance pathway
REACT_456
PKB-mediated events pathway
REACT_200686
Activation of PPARGC1A (PGC-1alpha) by phosphorylation pathway
REACT_200788
Mitochondrial biogenesis pathway
REACT_111102
Signal Transduction pathway
REACT_332
IRS-mediated signalling pathway
REACT_1195
Insulin receptor signalling cascade pathway
REACT_762
IRS-related events pathway
REACT_150210
IGF1R signaling cascade pathway
REACT_11123
Membrane Trafficking pathway
KEGG
hsa04710
Circadian rhythm pathway
hsa04910
Insulin signaling pathway pathway
hsa04920
Adipocytokine signaling pathway pathway
hsa05410
Hypertrophic cardiomyopathy (HCM) pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
Insulin receptor signaling pathway
INOH website
VEGF signaling pathway pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.733223
RefSeq NM_001206709 NM_001206710 NM_002733 XM_005269019 XM_005269020 XM_006719499 XM_006719500
HUGO
OMIM
CCDS CCDS55824 CCDS55825 CCDS8777
HPRD 04118
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca