InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PRKAG1

Summary

InnateDB Protein

IDBP-601477.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRKAG1

Protein Name

protein kinase, AMP-activated, gamma 1 non-catalytic subunit

Synonyms

AMPKG;

Species

Homo sapiens

Ensembl Protein

ENSP00000447433

InnateDB Gene

IDBG-30803 (PRKAG1)

Protein Structure

UniProt Annotation

Function

AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive. {ECO:0000269PubMed:21680840}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	28 [view]
Protein-Protein	27 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004679	AMP-activated protein kinase activity
GO:0004691	cAMP-dependent protein kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008603	cAMP-dependent protein kinase regulator activity
GO:0016208	AMP binding
GO:0019901	protein kinase binding
GO:0030554	adenyl nucleotide binding
GO:0043531	ADP binding

Biological Process

GO:0006110	regulation of glycolytic process
GO:0006468	protein phosphorylation
GO:0006633	fatty acid biosynthetic process
GO:0007050	cell cycle arrest
GO:0007165	signal transduction
GO:0007283	spermatogenesis
GO:0008286	insulin receptor signaling pathway
GO:0010628	positive regulation of gene expression
GO:0045860	positive regulation of protein kinase activity
GO:0061024	membrane organization