Homo sapiens Gene: EIF4E | |||||||||||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||||||||||
InnateDB Gene | IDBG-30970.6 | ||||||||||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||||||
Gene Symbol | EIF4E | ||||||||||||||||||||||||||||||||||
Gene Name | eukaryotic translation initiation factor 4E | ||||||||||||||||||||||||||||||||||
Synonyms | AUTS19; CBP; EIF4E1; EIF4EL1; EIF4F | ||||||||||||||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||||||||||||||
Ensembl Gene | ENSG00000151247 | ||||||||||||||||||||||||||||||||||
Encoded Proteins |
eukaryotic translation initiation factor 4E
eukaryotic translation initiation factor 4E
eukaryotic translation initiation factor 4E
eukaryotic translation initiation factor 4E
eukaryotic translation initiation factor 4E
eukaryotic translation initiation factor 4E
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Protein Structure | |||||||||||||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||||||||
InnateDB Annotation | |||||||||||||||||||||||||||||||||||
Summary |
The regulated phosphorylation of EIF4E has a key role in antiviral host defense by selectively controlling the translation of NFKBIA mRNA, which encodes a critical suppressor of the innate antiviral response. As a result, EIF4E null mice exhibit lower susceptibility to viral infections. (Demonstrated in mice)
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InnateDB Annotation from Orthologs | |||||||||||||||||||||||||||||||||||
Summary |
[Mus musculus] The regulated phosphorylation of Eif4e has a key role in antiviral host defense by selectively controlling the translation of Nfkbia mRNA, which encodes a critical suppressor of the innate antiviral response. As a result, Eif4e null mice exhibit lower susceptibility to viral infections.
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Entrez Gene | |||||||||||||||||||||||||||||||||||
Summary |
The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of cellular mRNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the mRNA. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012] The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5\' end of cellular mRNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the mRNA. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012] |
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Gene Information | |||||||||||||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||||||||||||
Genomic Location | Chromosome 4:98871684-98930637 | ||||||||||||||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||||||||||||||
Band | q23 | ||||||||||||||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||||||||||||||
Interactions | |||||||||||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 96 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||||||||||||||
NETPATH |
Alpha6Beta4Integrin pathway
IL2 pathway
IL6 pathway
Leptin pathway
TSLP pathway
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REACTOME |
ISG15 antiviral mechanism pathway
L13a-mediated translational silencing of Ceruloplasmin expression pathway
Release of eIF4E pathway
mTOR signalling pathway
PI3K Cascade pathway
Signaling by Insulin receptor pathway
IRS-related events triggered by IGF1R pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
Deadenylation of mRNA pathway
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
Translation initiation complex formation pathway
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S pathway
Ribosomal scanning and start codon recognition pathway
Transport of Mature mRNA derived from an Intron-Containing Transcript pathway
Transport of the SLBP independent Mature mRNA pathway
Transport of the SLBP Dependant Mature mRNA pathway
Transport of Mature mRNA Derived from an Intronless Transcript pathway
Processing of Capped Intron-Containing Pre-mRNA pathway
Eukaryotic Translation Initiation pathway
PKB-mediated events pathway
Deadenylation-dependent mRNA decay pathway
Antiviral mechanism by IFN-stimulated genes pathway
Cytokine Signaling in Immune system pathway
mTORC1-mediated signalling pathway
Translation pathway
Signal Transduction pathway
Interferon Signaling pathway
IRS-mediated signalling pathway
Metabolism of proteins pathway
Immune System pathway
Insulin receptor signalling cascade pathway
Transport of Mature Transcript to Cytoplasm pathway
Cap-dependent Translation Initiation pathway
IRS-related events pathway
IGF1R signaling cascade pathway
Transport of Mature mRNAs Derived from Intronless Transcripts pathway
Gene Expression pathway
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KEGG |
mTOR signaling pathway pathway
Insulin signaling pathway pathway
RNA transport pathway
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INOH |
Insulin receptor signaling pathway
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PID NCI |
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
mTOR signaling pathway
Validated targets of C-MYC transcriptional activation
Signaling mediated by p38-alpha and p38-beta
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Cross-References | |||||||||||||||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||||||||||||
UniGene | Hs.13211 Hs.596163 | ||||||||||||||||||||||||||||||||||
RefSeq | NM_001130678 NM_001130679 NM_001968 XM_006714127 | ||||||||||||||||||||||||||||||||||
HUGO | |||||||||||||||||||||||||||||||||||
OMIM | |||||||||||||||||||||||||||||||||||
CCDS | CCDS34031 CCDS47109 CCDS54779 | ||||||||||||||||||||||||||||||||||
HPRD | 00591 | ||||||||||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||||||||||
EMBL | |||||||||||||||||||||||||||||||||||
GenPept | |||||||||||||||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||||||||||||||