Version 5.4
| Bos taurus Gene: EIF4E | |||||||||||||||||
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| Summary | |||||||||||||||||
| InnateDB Gene | IDBG-640970.3 | ||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||
| Gene Symbol | EIF4E | ||||||||||||||||
| Gene Name | Eukaryotic translation initiation factor 4E | ||||||||||||||||
| Synonyms | |||||||||||||||||
| Species | Bos taurus | ||||||||||||||||
| Ensembl Gene | ENSBTAG00000009522 | ||||||||||||||||
| Encoded Proteins |
Eukaryotic translation initiation factor 4E
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||
| InnateDB Annotation from Orthologs | |||||||||||||||||
| Summary |
[Homo sapiens] The regulated phosphorylation of EIF4E has a key role in antiviral host defense by selectively controlling the translation of NFKBIA mRNA, which encodes a critical suppressor of the innate antiviral response. As a result, EIF4E null mice exhibit lower susceptibility to viral infections. (Demonstrated in mice)
[Mus musculus] The regulated phosphorylation of Eif4e has a key role in antiviral host defense by selectively controlling the translation of Nfkbia mRNA, which encodes a critical suppressor of the innate antiviral response. As a result, Eif4e null mice exhibit lower susceptibility to viral infections.
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| Entrez Gene | |||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000151247:
The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of cellular mRNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the mRNA. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012] The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5\' end of cellular mRNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the mRNA. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012] |
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| Gene Information | |||||||||||||||||
| Type | Protein coding | ||||||||||||||||
| Genomic Location | Chromosome 6:27042237-27080766 | ||||||||||||||||
| Strand | Forward strand | ||||||||||||||||
| Band | |||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 46 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathways | |||||||||||||||||
| NETPATH | |||||||||||||||||
| REACTOME |
Insulin receptor signalling cascade pathway
PKB-mediated events pathway
IRS-related events triggered by IGF1R pathway
Release of eIF4E pathway
Deadenylation of mRNA pathway
ISG15 antiviral mechanism pathway
Transport of Mature Transcript to Cytoplasm pathway
Transport of Mature mRNA Derived from an Intronless Transcript pathway
L13a-mediated translational silencing of Ceruloplasmin expression pathway
mTOR signalling pathway
Cytokine Signaling in Immune system pathway
mTORC1-mediated signalling pathway
IRS-related events pathway
Gene Expression pathway
Eukaryotic Translation Initiation pathway
Cap-dependent Translation Initiation pathway
Immune System pathway
IRS-mediated signalling pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
Antiviral mechanism by IFN-stimulated genes pathway
Transport of Mature mRNA derived from an Intron-Containing Transcript pathway
IGF1R signaling cascade pathway
Transport of the SLBP independent Mature mRNA pathway
Translation pathway
Processing of Capped Intron-Containing Pre-mRNA pathway
Signal Transduction pathway
Transport of the SLBP Dependant Mature mRNA pathway
PI3K Cascade pathway
Signaling by Insulin receptor pathway
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
Metabolism of proteins pathway
Interferon Signaling pathway
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S pathway
Translation initiation complex formation pathway
Transport of Mature mRNAs Derived from Intronless Transcripts pathway
Deadenylation-dependent mRNA decay pathway
Ribosomal scanning and start codon recognition pathway
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| KEGG | |||||||||||||||||
| INOH | |||||||||||||||||
| PID NCI | |||||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||||
| NETPATH |
Alpha6Beta4Integrin pathway
IL2 pathway
IL6 pathway
Leptin pathway
TSLP pathway
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| REACTOME |
ISG15 antiviral mechanism pathway
L13a-mediated translational silencing of Ceruloplasmin expression pathway
Release of eIF4E pathway
mTOR signalling pathway
PI3K Cascade pathway
Signaling by Insulin receptor pathway
IRS-related events triggered by IGF1R pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
Deadenylation of mRNA pathway
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
Translation initiation complex formation pathway
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S pathway
Ribosomal scanning and start codon recognition pathway
Transport of Mature mRNA derived from an Intron-Containing Transcript pathway
Transport of the SLBP independent Mature mRNA pathway
Transport of the SLBP Dependant Mature mRNA pathway
Transport of Mature mRNA Derived from an Intronless Transcript pathway
Processing of Capped Intron-Containing Pre-mRNA pathway
Eukaryotic Translation Initiation pathway
PKB-mediated events pathway
Deadenylation-dependent mRNA decay pathway
Antiviral mechanism by IFN-stimulated genes pathway
Cytokine Signaling in Immune system pathway
mTORC1-mediated signalling pathway
Translation pathway
Signal Transduction pathway
Interferon Signaling pathway
IRS-mediated signalling pathway
Metabolism of proteins pathway
Immune System pathway
Insulin receptor signalling cascade pathway
Transport of Mature Transcript to Cytoplasm pathway
Cap-dependent Translation Initiation pathway
IRS-related events pathway
IGF1R signaling cascade pathway
Transport of Mature mRNAs Derived from Intronless Transcripts pathway
Gene Expression pathway
Transport of Mature Transcript to Cytoplasm pathway
Signaling by Insulin receptor pathway
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S pathway
Cytokine Signaling in Immune system pathway
Deadenylation of mRNA pathway
Translation pathway
Antiviral mechanism by IFN-stimulated genes pathway
ISG15 antiviral mechanism pathway
Immune System pathway
Translation initiation complex formation pathway
Metabolism of proteins pathway
Release of eIF4E pathway
Cap-dependent Translation Initiation pathway
Eukaryotic Translation Initiation pathway
Insulin receptor signalling cascade pathway
IRS-related events triggered by IGF1R pathway
IGF1R signaling cascade pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
Interferon Signaling pathway
PI3K Cascade pathway
Gene Expression pathway
Transport of the SLBP independent Mature mRNA pathway
IRS-related events pathway
IRS-mediated signalling pathway
mTORC1-mediated signalling pathway
L13a-mediated translational silencing of Ceruloplasmin expression pathway
Transport of Mature mRNA Derived from an Intronless Transcript pathway
Signal Transduction pathway
Ribosomal scanning and start codon recognition pathway
Transport of Mature mRNAs Derived from Intronless Transcripts pathway
mTOR signalling pathway
Transport of Mature mRNA derived from an Intron-Containing Transcript pathway
PKB-mediated events pathway
Transport of the SLBP Dependant Mature mRNA pathway
Processing of Capped Intron-Containing Pre-mRNA pathway
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
Deadenylation-dependent mRNA decay pathway
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| KEGG |
mTOR signaling pathway pathway
Insulin signaling pathway pathway
RNA transport pathway
Insulin signaling pathway pathway
mTOR signaling pathway pathway
RNA transport pathway
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| INOH |
Insulin receptor signaling pathway
Insulin receptor signaling pathway
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| PID NCI |
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
mTOR signaling pathway
Validated targets of C-MYC transcriptional activation
Signaling mediated by p38-alpha and p38-beta
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| Cross-References | |||||||||||||||||
| SwissProt | Q9N0T5 | ||||||||||||||||
| TrEMBL | |||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||
| Entrez Gene | 281751 | ||||||||||||||||
| UniGene | Bt.1148 Bt.67986 Bt.97370 | ||||||||||||||||
| RefSeq | NM_174310 XM_005207713 XM_005207714 XM_005207715 XM_005207716 XM_005207717 | ||||||||||||||||
| HUGO | |||||||||||||||||
| OMIM | |||||||||||||||||
| CCDS | |||||||||||||||||
| HPRD | |||||||||||||||||
| IMGT | |||||||||||||||||
| EMBL | AF257235 BC111272 | ||||||||||||||||
| GenPept | AAF66991 AAI11273 | ||||||||||||||||
| RNA Seq Atlas | 281751 | ||||||||||||||||