Homo sapiens Gene: JUNB
Summary
InnateDB Gene IDBG-30976.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol JUNB
Gene Name jun B proto-oncogene
Synonyms AP-1
Species Homo sapiens
Ensembl Gene ENSG00000171223
Encoded Proteins
jun B proto-oncogene
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 19:12791496-12793315
Strand Forward strand
Band p13.13
Transcripts
ENST00000302754 ENSP00000303315
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 79 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 79 [view]
Protein-Protein 72 [view]
Protein-DNA 7 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003690 double-stranded DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003713 transcription coactivator activity
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0001570 vasculogenesis
GO:0001649 osteoblast differentiation
GO:0001701 in utero embryonic development
GO:0001829 trophectodermal cell differentiation
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007565 female pregnancy
GO:0009416 response to light stimulus
GO:0009612 response to mechanical stimulus
GO:0009987 cellular process
GO:0010467 gene expression
GO:0014070 response to organic cyclic compound
GO:0030316 osteoclast differentiation
GO:0032570 response to progesterone
GO:0032870 cellular response to hormone stimulus
GO:0033687 osteoblast proliferation
GO:0034097 response to cytokine
GO:0042493 response to drug
GO:0043434 response to peptide hormone
GO:0045597 positive regulation of cell differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046697 decidualization
GO:0051412 response to corticosterone
GO:0051591 response to cAMP
GO:0051726 regulation of cell cycle
GO:0060136 embryonic process involved in female pregnancy
GO:0060716 labyrinthine layer blood vessel development
GO:0071277 cellular response to calcium ion
Cellular Component
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
TGF_beta_Receptor pathway
TNFalpha pathway
BCR pathway
TSLP pathway
Oncostatin_M pathway
REACTOME
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription pathway
Generic Transcription Pathway pathway
SMAD4 MH2 Domain Mutants in Cancer pathway
Loss of Function of SMAD4 in Cancer pathway
Loss of Function of SMAD2/3 in Cancer pathway
Signaling by TGF-beta Receptor Complex in Cancer pathway
TGFBR2 MSI Frameshift Mutants in Cancer pathway
Signal Transduction pathway
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway
SMAD2/3 MH2 Domain Mutants in Cancer pathway
Loss of Function of TGFBR2 in Cancer pathway
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
TGFBR1 KD Mutants in Cancer pathway
Loss of Function of TGFBR1 in Cancer pathway
TGFBR1 LBD Mutants in Cancer pathway
TGFBR2 Kinase Domain Mutants in Cancer pathway
Gene Expression pathway
Disease pathway
Signaling by TGF-beta Receptor Complex pathway
KEGG
Osteoclast differentiation pathway
INOH
PID NCI
Calcium signaling in the CD4+ TCR pathway
Validated transcriptional targets of AP1 family members Fra1 and Fra2
Downstream signaling in naïve CD8+ T cells
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
ATF-2 transcription factor network
AP-1 transcription factor network
IL6-mediated signaling events
Cross-References
SwissProt P17275
TrEMBL Q5U079
UniProt Splice Variant
Entrez Gene 3726
UniGene Hs.25292
RefSeq NM_002229
HUGO HGNC:6205
OMIM 165161
CCDS CCDS12280
HPRD
IMGT
EMBL AK313737 AY751746 BC004250 BC009465 BC009466 BT019760 CH471106 M29039 U20734 X51345
GenPept AAA59198 AAA74915 AAH04250 AAH09465 AAH09466 AAU43800 AAV38565 BAG36478 CAA35738 EAW84307
RNA Seq Atlas 3726