InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: JUNB

Summary

InnateDB Protein

IDBP-30978.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

JUNB

Protein Name

jun B proto-oncogene

Synonyms

AP-1;

Species

Homo sapiens

Ensembl Protein

ENSP00000303315

InnateDB Gene

IDBG-30976 (JUNB)

Protein Structure

UniProt Annotation

Function

Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5'-TGA[CG]TCA-3'.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 79 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	79 [view]
Protein-Protein	72 [view]
Protein-DNA	7 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003690	double-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003713	transcription coactivator activity
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0001570	vasculogenesis
GO:0001649	osteoblast differentiation
GO:0001701	in utero embryonic development
GO:0001829	trophectodermal cell differentiation
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007565	female pregnancy
GO:0009416	response to light stimulus
GO:0009612	response to mechanical stimulus
GO:0009987	cellular process
GO:0010467	gene expression
GO:0014070	response to organic cyclic compound
GO:0030316	osteoclast differentiation
GO:0032570	response to progesterone
GO:0032870	cellular response to hormone stimulus
GO:0033687	osteoblast proliferation
GO:0034097	response to cytokine
GO:0042493	response to drug
GO:0043434	response to peptide hormone
GO:0045597	positive regulation of cell differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046697	decidualization
GO:0051412	response to corticosterone
GO:0051591	response to cAMP
GO:0051726	regulation of cell cycle
GO:0060136	embryonic process involved in female pregnancy
GO:0060716	labyrinthine layer blood vessel development
GO:0071277	cellular response to calcium ion

Cellular Component

GO:0000785	chromatin
GO:0005634	nucleus
GO:0005654	nucleoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR002112 Transcription factor Jun
IPR004827 Basic-leucine zipper domain
IPR005643 Jun-like transcription factor
IPR008917 Transcription factor, Skn-1-like, DNA-binding domain

PFAM

PF00170
PF07716
PF03957

PRINTS

PR00043

PIRSF

SMART

SM00338

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt