Version 5.4
| Homo sapiens Gene: PILRB | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-31079.5 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | PILRB | ||||||||||||||||||
| Gene Name | paired immunoglobin-like type 2 receptor beta | ||||||||||||||||||
| Synonyms | |||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000121716 | ||||||||||||||||||
| Encoded Proteins |
paired immunoglobin-like type 2 receptor beta
paired immunoglobin-like type 2 receptor beta
paired immunoglobin-like type 2 receptor beta
paired immunoglobin-like type 2 receptor beta
paired immunoglobin-like type 2 receptor beta
paired immunoglobin-like type 2 receptor beta
paired immunoglobin-like type 2 receptor beta
paired immunoglobin-like type 2 receptor beta
paired immunoglobin-like type 2 receptor beta
paired immunoglobin-like type 2 receptor beta
paired immunoglobin-like type 2 receptor beta
paired immunoglobin-like type 2 receptor beta
paired immunoglobin-like type 2 receptor beta
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| Protein Structure | |||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
The paired immunoglobin-like type 2 receptors consist of highly related activating and inhibitory receptors that are involved in the regulation of many aspects of the immune system. The paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This gene encodes the activating member of the receptor pair and contains a truncated cytoplasmic tail relative to its inhibitory counterpart (PILRA), that has a long cytoplasmic tail with immunoreceptor tyrosine-based inhibitory (ITIM) motifs. This gene is thought to have arisen from a duplication of the inhibitory PILRA gene and evolved to acquire its activating function. Alternatively spliced transcript variants have been noted for this gene, but the full-length nature of many is not known. [provided by RefSeq, Nov 2012] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 7:100352176-100367733 | ||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||
| Band | q22.1 | ||||||||||||||||||
| Transcripts | |||||||||||||||||||
| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
| No orthologs found for this gene | |||||||||||||||||||
| Pathways | |||||||||||||||||||
| NETPATH |
IL3 pathway
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| REACTOME | |||||||||||||||||||
| KEGG | |||||||||||||||||||
| INOH | |||||||||||||||||||
| PID NCI | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | |||||||||||||||||||
| TrEMBL | |||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| UniGene | Hs.632314 Hs.713510 | ||||||||||||||||||
| RefSeq | NM_178238 | ||||||||||||||||||
| HUGO | |||||||||||||||||||
| OMIM | |||||||||||||||||||
| CCDS | CCDS43622 | ||||||||||||||||||
| HPRD | |||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | |||||||||||||||||||
| GenPept | |||||||||||||||||||
| RNA Seq Atlas | |||||||||||||||||||