Version 5.4
Homo sapiens Gene: ADH4
Summary
InnateDB Gene IDBG-31122.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADH4
Gene Name alcohol dehydrogenase 4 (class II), pi polypeptide
Synonyms ADH-2; HEL-S-4
Species Homo sapiens
Ensembl Gene ENSG00000198099
Encoded Proteins
IDBP-31124
alcohol dehydrogenase 4 (class II), pi polypeptide
IDBP-485007
alcohol dehydrogenase 4 (class II), pi polypeptide
IDBP-481454
alcohol dehydrogenase 4 (class II), pi polypeptide
IDBP-483375
alcohol dehydrogenase 4 (class II), pi polypeptide
IDBP-478341
alcohol dehydrogenase 4 (class II), pi polypeptide
IDBP-477226
alcohol dehydrogenase 4 (class II), pi polypeptide
IDBP-474279
alcohol dehydrogenase 4 (class II), pi polypeptide
IDBP-475355
alcohol dehydrogenase 4 (class II), pi polypeptide
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes class II alcohol dehydrogenase 4 pi subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class II alcohol dehydrogenase is a homodimer composed of 2 pi subunits. It exhibits a high activity for oxidation of long-chain aliphatic alcohols and aromatic alcohols and is less sensitive to pyrazole. This gene is localized to chromosome 4 in the cluster of alcohol dehydrogenase genes. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:99123657-99157792
Strand Reverse strand
Band q23
Transcripts
ENST00000265512 ENSP00000265512
ENST00000508393 ENSP00000424630
ENST00000509471 ENSP00000424583
ENST00000505590 ENSP00000425416
ENST00000506705 ENSP00000426667
ENST00000512499 ENSP00000423571
ENST00000503416
ENST00000504125 ENSP00000427525
ENST00000503944
ENST00000504894 ENSP00000427261
ENST00000504581
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 4 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003960 NADPH:quinone reductase activity
GO:0004022 alcohol dehydrogenase (NAD) activity
GO:0004024 alcohol dehydrogenase activity, zinc-dependent
GO:0004032 alditol:NADP+ 1-oxidoreductase activity
GO:0004745 retinol dehydrogenase activity
GO:0005503 all-trans retinal binding
GO:0008270 zinc ion binding
GO:0016491 oxidoreductase activity
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups
GO:0019115 benzaldehyde dehydrogenase activity
GO:0019841 retinol binding
GO:0035276 ethanol binding
GO:0051287 NAD binding
Biological Process
GO:0001523 retinoid metabolic process
GO:0006066 alcohol metabolic process
GO:0006067 ethanol metabolic process
GO:0006069 ethanol oxidation
GO:0006081 cellular aldehyde metabolic process
GO:0006805 xenobiotic metabolic process
GO:0042572 retinol metabolic process
GO:0044281 small molecule metabolic process
GO:0046164 alcohol catabolic process
GO:0055114 oxidation-reduction process
GO:1901661 quinone metabolic process
Cellular Component
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000037797
View Gene Order
ENSBTAG00000034139
Not yet available
Pathways
NETPATH
REACTOME
REACT_34
Ethanol oxidation pathway
REACT_111217
Metabolism pathway
REACT_13433
Biological oxidations pathway
REACT_13705
Phase 1 - Functionalization of compounds pathway
KEGG
hsa00010
Glycolysis / Gluconeogenesis pathway
hsa00830
Retinol metabolism pathway
hsa00071
Fatty acid degradation pathway
hsa00350
Tyrosine metabolism pathway
hsa00980
Metabolism of xenobiotics by cytochrome P450 pathway
hsa00982
Drug metabolism pathway
INOH
INOH website
Tyrosine metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL D6RIB1
UniProt Splice Variant
Entrez Gene 127
UniGene Hs.1219 Hs.611849 Hs.740127
RefSeq NM_000670
HUGO HGNC:252
OMIM 103740
CCDS CCDS34032
HPRD 00068
IMGT
EMBL AC019131 AP002026
GenPept
RNA Seq Atlas 127

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca