InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ADH4

Summary

InnateDB Protein

IDBP-483375.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADH4

Protein Name

alcohol dehydrogenase 4 (class II), pi polypeptide

Synonyms

ADH-2; HEL-S-4;

Species

Homo sapiens

Ensembl Protein

ENSP00000425416

InnateDB Gene

IDBG-31122 (ADH4)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003960	NADPH:quinone reductase activity
GO:0004022	alcohol dehydrogenase (NAD) activity
GO:0004024	alcohol dehydrogenase activity, zinc-dependent
GO:0004745	retinol dehydrogenase activity
GO:0005503	all-trans retinal binding
GO:0008270	zinc ion binding
GO:0016491	oxidoreductase activity
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups
GO:0019115	benzaldehyde dehydrogenase activity
GO:0019841	retinol binding
GO:0035276	ethanol binding
GO:0051287	NAD binding

Biological Process

GO:0001523	retinoid metabolic process
GO:0006066	alcohol metabolic process
GO:0006069	ethanol oxidation
GO:0006081	cellular aldehyde metabolic process
GO:0006805	xenobiotic metabolic process
GO:0042572	retinol metabolic process
GO:0044281	small molecule metabolic process
GO:0046164	alcohol catabolic process
GO:0055114	oxidation-reduction process
GO:1901661	quinone metabolic process

Cellular Component

GO:0005829

cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR011032 GroES (chaperonin 10)-like
IPR013149 Alcohol dehydrogenase, C-terminal
IPR013154 Alcohol dehydrogenase GroES-like
IPR020843 Polyketide synthase, enoylreductase

PFAM

PF00107
PF08240

PRINTS

PIRSF

SMART

SM00829

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P08319