InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GCDH

Summary

InnateDB Gene

IDBG-31277.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GCDH

Gene Name

glutaryl-CoA dehydrogenase

Synonyms

ACAD5; GCD

Species

Homo sapiens

Ensembl Gene

ENSG00000105607

Encoded Proteins

IDBP-31279

glutaryl-CoA dehydrogenase

IDBP-765716

IDBP-760764

IDBP-764826

IDBP-764864

IDBP-763581

IDBP-760530

IDBP-761185

IDBP-765772

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene belongs to the acyl-CoA dehydrogenase family. It catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor. The enzyme exists in the mitochondrial matrix as a homotetramer of 45-kD subunits. Mutations in this gene result in the metabolic disorder glutaric aciduria type 1, which is also known as glutaric acidemia type I. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 12. [provided by RefSeq, Mar 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:12891026-12914207

Strand

Forward strand

Band

p13.13

Transcripts

ENST00000222214	ENSP00000222214
ENST00000421816
ENST00000591470	ENSP00000466845
ENST00000588242
ENST00000590627
ENST00000590445	ENSP00000468125
ENST00000585420
ENST00000589039	ENSP00000465618
ENST00000590472	ENSP00000468625
ENST00000585760
ENST00000590530	ENSP00000468452
ENST00000587072	ENSP00000468584
ENST00000591050	ENSP00000467735
ENST00000587832
ENST00000591043
ENST00000588905	ENSP00000465770

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.

Experimentally validated
Total	16 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000062	fatty-acyl-CoA binding
GO:0003995	acyl-CoA dehydrogenase activity
GO:0004361	glutaryl-CoA dehydrogenase activity
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors
GO:0050660	flavin adenine dinucleotide binding

Biological Process

GO:0006554	lysine catabolic process
GO:0006568	tryptophan metabolic process
GO:0006637	acyl-CoA metabolic process
GO:0008152	metabolic process
GO:0019395	fatty acid oxidation
GO:0034641	cellular nitrogen compound metabolic process
GO:0044281	small molecule metabolic process
GO:0046949	fatty-acyl-CoA biosynthetic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005759	mitochondrial matrix

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000003809

View Gene Order

ENSBTAG00000016211

Not yet available

Pathways

NETPATH

REACTOME

REACT_1298

Lysine catabolism pathway

REACT_13

Metabolism of amino acids and derivatives pathway

REACT_111217

Metabolism pathway

KEGG

hsa00380

Tryptophan metabolism pathway

hsa00071

Fatty acid degradation pathway

hsa00310

Lysine degradation pathway

INOH

INOH website

Tryptophan degradation pathway

INOH website

Lysine degradation pathway

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.532699 Hs.666526

RefSeq

NM_000159 NM_013976 XM_006722721

HUGO

OMIM

CCDS

CCDS12286

HPRD

01977

IMGT

EMBL

GenPept

RNA Seq Atlas