InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Gcdh

Summary

InnateDB Gene

IDBG-175137.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gcdh

Gene Name

glutaryl-Coenzyme A dehydrogenase

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000003809

Encoded Proteins

IDBP-175139

glutaryl-Coenzyme A dehydrogenase

IDBP-261730

glutaryl-Coenzyme A dehydrogenase

IDBP-536511

glutaryl-Coenzyme A dehydrogenase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000105607:
The protein encoded by this gene belongs to the acyl-CoA dehydrogenase family. It catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor. The enzyme exists in the mitochondrial matrix as a homotetramer of 45-kD subunits. Mutations in this gene result in the metabolic disorder glutaric aciduria type 1, which is also known as glutaric acidemia type I. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 12. [provided by RefSeq, Mar 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:84886393-84893921

Strand

Reverse strand

Band

Transcripts

ENSMUST00000003907	ENSMUSP00000003907
ENSMUST00000109745	ENSMUSP00000105367
ENSMUST00000139180
ENSMUST00000136462
ENSMUST00000128023
ENSMUST00000142748	ENSMUSP00000116584

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000062	fatty-acyl-CoA binding
GO:0003995	acyl-CoA dehydrogenase activity
GO:0004361	glutaryl-CoA dehydrogenase activity
GO:0016491	oxidoreductase activity
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors
GO:0050660	flavin adenine dinucleotide binding

Biological Process

GO:0006568	tryptophan metabolic process
GO:0006637	acyl-CoA metabolic process
GO:0008152	metabolic process
GO:0019395	fatty acid oxidation
GO:0046949	fatty-acyl-CoA biosynthetic process
GO:0055114	oxidation-reduction process