Version 5.4
Homo sapiens Gene: DAND5
Summary
InnateDB Gene IDBG-31601.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DAND5
Gene Name DAN domain family, member 5
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000179284
Encoded Proteins
IDBP-31603
DAN domain family, member 5
IDBP-764760
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to bind Nodal and to inhibit the Nodal signaling pathway which patterns left/right body asymmetry. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:12965159-12974762
Strand Forward strand
Band p13.13
Transcripts
ENST00000317060 ENSP00000323155
ENST00000585548 ENSP00000467806
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0016015 morphogen activity
Biological Process
GO:0003140 determination of left/right asymmetry in lateral mesoderm
GO:0003281 ventricular septum development
GO:0003283 atrial septum development
GO:0007368 determination of left/right symmetry
GO:0017015 regulation of transforming growth factor beta receptor signaling pathway
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030514 negative regulation of BMP signaling pathway
GO:0038101 sequestering of nodal from receptor via nodal binding
GO:0061371 determination of heart left/right asymmetry
GO:1900108 negative regulation of nodal signaling pathway
Cellular Component
GO:0005576 extracellular region
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000053226
View Gene Order
Cross-References
SwissProt Q8N907
TrEMBL K7EQF6
UniProt Splice Variant
Entrez Gene 199699
UniGene Hs.331981
RefSeq NM_152654
HUGO HGNC:26780
OMIM 609068
CCDS CCDS12291
HPRD
IMGT
EMBL AB070695 AC092069 AK095926 BC101800 BC113476 CH471106
GenPept AAI01801 AAI13477 BAC04651 BAC82440 EAW84337
RNA Seq Atlas 199699

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca