InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DAND5

Summary

InnateDB Protein

IDBP-31603.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DAND5

Protein Name

DAN domain family, member 5

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000323155

InnateDB Gene

IDBG-31601 (DAND5)

Protein Structure

UniProt Annotation

Function

Seems to play a role in the correct specification of the left-right axis. May antagonize NODAL and BMP4 signaling. Cystine knot-containing proteins play important roles during development, organogenesis, tissue growth and differentiation (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0016015	morphogen activity

Biological Process

GO:0003140	determination of left/right asymmetry in lateral mesoderm
GO:0003281	ventricular septum development
GO:0003283	atrial septum development
GO:0007368	determination of left/right symmetry
GO:0017015	regulation of transforming growth factor beta receptor signaling pathway
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030514	negative regulation of BMP signaling pathway
GO:0038101	sequestering of nodal from receptor via nodal binding
GO:0061371	determination of heart left/right asymmetry
GO:1900108	negative regulation of nodal signaling pathway