InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: FZD6

Summary

InnateDB Gene

IDBG-31669.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FZD6

Gene Name

frizzled family receptor 6

Synonyms

FZ-6; FZ6; HFZ6; NDNC10

Species

Homo sapiens

Ensembl Gene

ENSG00000164930

Encoded Proteins

IDBP-31671

frizzled family receptor 6

IDBP-473807

frizzled family receptor 6

IDBP-481489

frizzled family receptor 6

IDBP-476393

frizzled family receptor 6

IDBP-474920

frizzled family receptor 6

IDBP-481804

frizzled family receptor 6

IDBP-476283

frizzled family receptor 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide.[provided by RefSeq, Aug 2011]
This gene represents a member of the \'frizzled\' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide.[provided by RefSeq, Aug 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:103298433-103332866

Strand

Forward strand

Band

q22.3

Transcripts

ENST00000358755	ENSP00000351605
ENST00000522566	ENSP00000429055
ENST00000522484	ENSP00000428301
ENST00000523933	ENSP00000428257
ENST00000523739	ENSP00000429528
ENST00000519011	ENSP00000427733
ENST00000521195	ENSP00000428188

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding
GO:0017147	Wnt-protein binding
GO:0030165	PDZ domain binding
GO:0031625	ubiquitin protein ligase binding
GO:0042813	Wnt-activated receptor activity

Biological Process

GO:0001525	angiogenesis
GO:0001736	establishment of planar polarity
GO:0001843	neural tube closure
GO:0001942	hair follicle development
GO:0007166	cell surface receptor signaling pathway
GO:0007199	G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
GO:0007275	multicellular organismal development
GO:0007409	axonogenesis
GO:0008406	gonad development
GO:0016055	Wnt signaling pathway
GO:0030168	platelet activation
GO:0030901	midbrain development
GO:0033278	cell proliferation in midbrain
GO:0035567	non-canonical Wnt signaling pathway
GO:0035880	embryonic nail plate morphogenesis
GO:0042472	inner ear morphogenesis
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0060071	Wnt signaling pathway, planar cell polarity pathway
GO:0090090	negative regulation of canonical Wnt signaling pathway

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016327	apicolateral plasma membrane
GO:0032589	neuron projection membrane
GO:0045177	apical part of cell