Version 5.4
Homo sapiens Gene: LYL1
Summary
InnateDB Gene IDBG-31743.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LYL1
Gene Name lymphoblastic leukemia derived sequence 1
Synonyms bHLHa18
Species Homo sapiens
Ensembl Gene ENSG00000104903
Encoded Proteins
IDBP-31745
lymphoblastic leukemia derived sequence 1
IDBP-761959
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene represents a basic helix-loop-helix transcription factor. The encoded protein may play roles in blood vessel maturation and hematopoeisis. A translocation between this locus and the T cell receptor beta locus (GeneID 6957) on chromosome 7 has been associated with acute lymphoblastic leukemia. [provided by RefSeq, Sep 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:13099033-13103161
Strand Reverse strand
Band p13.13
Transcripts
ENST00000264824 ENSP00000264824
ENST00000590120
ENST00000590974 ENSP00000468122
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 89 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 89 [view]
Protein-Protein 11 [view]
Protein-DNA 78 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0046983 protein dimerization activity
Biological Process
GO:0001955 blood vessel maturation
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0030183 B cell differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0060216 definitive hemopoiesis
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000034041
View Gene Order
ENSBTAG00000019329
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.46446
RefSeq NM_005583
HUGO
OMIM
CCDS CCDS12292
HPRD 01046
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca