InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LYL1

Summary

InnateDB Protein

IDBP-31745.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LYL1

Protein Name

lymphoblastic leukemia derived sequence 1

Synonyms

bHLHa18;

Species

Homo sapiens

Ensembl Protein

ENSP00000264824

InnateDB Gene

IDBG-31743 (LYL1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00981}.

Disease Associations

Note=A chromosomal aberration involving LYL1 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(7;19)(q35;p13) with TCRB.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 89 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	89 [view]
Protein-Protein	11 [view]
Protein-DNA	78 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0046983	protein dimerization activity

Biological Process

GO:0001955	blood vessel maturation
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0030183	B cell differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0060216	definitive hemopoiesis