Version 5.4
Homo sapiens Gene: CTIF
Summary
InnateDB Gene IDBG-3179.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CTIF
Gene Name CBP80/20-dependent translation initiation factor
Synonyms Gm672; KIAA0427
Species Homo sapiens
Ensembl Gene ENSG00000134030
Encoded Proteins
IDBP-3181
CBP80/20-dependent translation initiation factor
IDBP-3183
CBP80/20-dependent translation initiation factor
IDBP-726568
IDBP-727444
IDBP-726918
IDBP-726990
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary CTIF is a component of the CBP80 (NCBP1; MIM 600469)/CBP20 (NCBP2; MIM 605133) translation initiation complex that binds cotranscriptionally to the cap end of nascent mRNA. The CBP80/CBP20 complex is involved in a simultaneous editing and translation step that recognizes premature termination codons (PTCs) in mRNAs and directs PTC-containing mRNAs toward nonsense-mediated decay (NMD). On mRNAs without PTCs, the CBP80/CBP20 complex is replaced with cytoplasmic mRNA cap-binding proteins, including EIF4G (MIM 600495), and steady-state translation of the mRNAs resumes in the cytoplasm (Kim et al., 2009 [PubMed 19648179]).[supplied by OMIM, Dec 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:48539046-48863217
Strand Forward strand
Band q21.1
Transcripts
ENST00000256413 ENSP00000256413
ENST00000382998 ENSP00000372459
ENST00000590422
ENST00000589585
ENST00000587860
ENST00000587752 ENSP00000465405
ENST00000591387 ENSP00000467425
ENST00000588345 ENSP00000467957
ENST00000592658
ENST00000587769
ENST00000591412 ENSP00000467965
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0005488 binding
GO:0005515 protein binding
Biological Process
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0006446 regulation of translational initiation
Cellular Component
GO:0005737 cytoplasm
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000052928
View Gene Order
ENSBTAG00000018901
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.145230 Hs.611200 Hs.623413
RefSeq NM_001142397 NM_014772 XM_006722587 XM_006722588 XM_006722589
HUGO
OMIM
CCDS CCDS11935 CCDS45864
HPRD 11083
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca