InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: LYVE1

Summary

InnateDB Gene

IDBG-31795.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LYVE1

Gene Name

lymphatic vessel endothelial hyaluronan receptor 1

Synonyms

CRSBP-1; HAR; LYVE-1; XLKD1

Species

Homo sapiens

Ensembl Gene

ENSG00000133800

Encoded Proteins

IDBP-31797

lymphatic vessel endothelial hyaluronan receptor 1

IDBP-366212

lymphatic vessel endothelial hyaluronan receptor 1

IDBP-596004

lymphatic vessel endothelial hyaluronan receptor 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a type I integral membrane glycoprotein. The encoded protein acts as a receptor and binds to both soluble and immobilized hyaluronan. This protein may function in lymphatic hyaluronan transport and have a role in tumor metastasis. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:10556966-10611689

Strand

Reverse strand

Band

p15.4

Transcripts

ENST00000256178	ENSP00000256178
ENST00000438354	ENSP00000402580
ENST00000529598	ENSP00000436016
ENST00000531706

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0004888	transmembrane signaling receptor activity
GO:0005540	hyaluronic acid binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006027	glycosaminoglycan catabolic process
GO:0006810	transport
GO:0006928	cellular component movement
GO:0007155	cell adhesion
GO:0007160	cell-matrix adhesion
GO:0007165	signal transduction
GO:0009611	response to wounding
GO:0009653	anatomical structure morphogenesis
GO:0030203	glycosaminoglycan metabolic process
GO:0030212	hyaluronan metabolic process
GO:0030214	hyaluronan catabolic process
GO:0044281	small molecule metabolic process

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome
GO:0071944	cell periphery