InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LYVE1

Summary

InnateDB Protein

IDBP-31797.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LYVE1

Protein Name

lymphatic vessel endothelial hyaluronan receptor 1

Synonyms

CRSBP-1; HAR; LYVE-1; XLKD1;

Species

Homo sapiens

Ensembl Protein

ENSP00000256178

InnateDB Gene

IDBG-31795 (LYVE1)

Protein Structure

UniProt Annotation

Function

Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes. {ECO:0000269PubMed:10037799}.

Subcellular Localization

Membrane {ECO:0000269PubMed:10037799}; Single-pass type I membrane protein {ECO:0000269PubMed:10037799}. Note=Localized to the plasma membrane and in vesicles near extranuclear membranes which may represent trans-Golgi network (TGN) and endosomes/prelysosomeal compartments. Undergoes ligand- dependent internalization and recycling at the cell surface.

Disease Associations

Tissue Specificity

Mainly expressed in endothelial cells lining lymphatic vessels. {ECO:0000269PubMed:10037799}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0004888	transmembrane signaling receptor activity
GO:0005540	hyaluronic acid binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006027	glycosaminoglycan catabolic process
GO:0006810	transport
GO:0006928	cellular component movement
GO:0007155	cell adhesion
GO:0007160	cell-matrix adhesion
GO:0007165	signal transduction
GO:0009611	response to wounding
GO:0009653	anatomical structure morphogenesis
GO:0030203	glycosaminoglycan metabolic process
GO:0030212	hyaluronan metabolic process
GO:0030214	hyaluronan catabolic process
GO:0044281	small molecule metabolic process

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome
GO:0071944	cell periphery