Version 5.4
Homo sapiens Gene: MRVI1
Summary
InnateDB Gene IDBG-31828.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MRVI1
Gene Name murine retrovirus integration site 1 homolog
Synonyms IRAG; JAW1L
Species Homo sapiens
Ensembl Gene ENSG00000072952
Encoded Proteins
IDBP-366293
murine retrovirus integration site 1 homolog
IDBP-366309
murine retrovirus integration site 1 homolog
IDBP-596081
murine retrovirus integration site 1 homolog
IDBP-591280
murine retrovirus integration site 1 homolog
IDBP-584850
murine retrovirus integration site 1 homolog
IDBP-585211
murine retrovirus integration site 1 homolog
IDBP-602923
murine retrovirus integration site 1 homolog
IDBP-588983
murine retrovirus integration site 1 homolog
IDBP-597275
murine retrovirus integration site 1 homolog
IDBP-595913
murine retrovirus integration site 1 homolog
IDBP-588259
murine retrovirus integration site 1 homolog
IDBP-584113
murine retrovirus integration site 1 homolog
IDBP-601385
murine retrovirus integration site 1 homolog
IDBP-595906
murine retrovirus integration site 1 homolog
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is similar to a putative mouse tumor suppressor gene (Mrvi1) that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein, which is found in the membrane of the endoplasmic reticulum, is similar to Jaw1, a lymphoid-restricted protein whose expression is down-regulated during lymphoid differentiation. This protein is a substrate of cGMP-dependent kinase-1 (PKG1) that can function as a regulator of IP3-induced calcium release. Studies in mouse suggest that MRV integration at Mrvi1 induces myeloid leukemia by altering the expression of a gene important for myeloid cell growth and/or differentiation, and thus this gene may function as a myeloid leukemia tumor suppressor gene. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene, and alternative translation start sites, including a non-AUG (CUG) start site, are used. [provided by RefSeq, May 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:10573091-10693988
Strand Reverse strand
Band p15.4
Transcripts
ENST00000423302 ENSP00000412130
ENST00000424001 ENSP00000401205
ENST00000558540 ENSP00000453013
ENST00000541483 ENSP00000437784
ENST00000531107 ENSP00000432436
ENST00000527509 ENSP00000432067
ENST00000534266 ENSP00000433296
ENST00000529448 ENSP00000434741
ENST00000526414 ENSP00000435658
ENST00000529471
ENST00000533631 ENSP00000431845
ENST00000532037
ENST00000529547 ENSP00000432325
ENST00000531786
ENST00000529068 ENSP00000433970
ENST00000531308 ENSP00000432312
ENST00000547195 ENSP00000448278
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007596 blood coagulation
GO:0019934 cGMP-mediated signaling
GO:0045986 negative regulation of smooth muscle contraction
GO:0060087 relaxation of vascular smooth muscle
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
GO:0016529 sarcoplasmic reticulum
GO:0031095 platelet dense tubular network membrane
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000005611
View Gene Order
ENSBTAG00000007129
Not yet available
Pathways
NETPATH
REACTOME
REACT_23767
cGMP effects pathway
REACT_23862
Nitric oxide stimulates guanylate cyclase pathway
REACT_23876
Platelet homeostasis pathway
REACT_604
Hemostasis pathway
KEGG
hsa04270
Vascular smooth muscle contraction pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.501898 Hs.680194 Hs.740156
RefSeq NM_001098579 NM_001100163 NM_001100167 NM_001206880 NM_001206881 NM_130385
HUGO
OMIM
CCDS CCDS44538 CCDS44539 CCDS44540 CCDS55745 CCDS55746
HPRD 05242
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca