Version 5.4
Homo sapiens Protein: MRVI1
Summary
InnateDB Protein IDBP-366309.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MRVI1
Protein Name murine retrovirus integration site 1 homolog
Synonyms IRAG; JAW1L;
Species Homo sapiens
Ensembl Protein ENSP00000401205
InnateDB Gene IDBG-31828 (MRVI1)
Protein Structure
UniProt Annotation
Function Plays a role as NO/PRKG1-dependent regulator of IP3- induced calcium release; its phosphorylation by PRKG1 inhibits bradykinin and IP3-induced calcium release from intracellular stores. Recruits PRKG1 to the endoplasmic reticulum and may mediate the assembly of PRKG1 and ITPR1 in a macrocomplex. Involved in PRKG1 signaling cascade leading to inhibition of platelet activation and aggregation. Mediates also NO-dependent inhibition of calcium signaling in gastrointestinal smooth muscle contributing to NO-dependent relaxation. {ECO:0000269PubMed:14729908}.
Subcellular Localization Cytoplasm, perinuclear region. Sarcoplasmic reticulum {ECO:0000250}. Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Expressed in the colon, rectum, and cultured colonic smooth muscle. Detected in various cancer cell lines. {ECO:0000269PubMed:10321731, ECO:0000269PubMed:14729908}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007596 blood coagulation
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
GO:0016529 sarcoplasmic reticulum
GO:0031095 platelet dense tubular network membrane
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR008677 MRVI1
PFAM PF05781
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y6F6
PhosphoSite PhosphoSite-Q9Y6F6
TrEMBL
UniProt Splice Variant
Entrez Gene 10335
UniGene Hs.740156
RefSeq
HUGO HGNC:7237
OMIM 604673
CCDS CCDS44540
HPRD 05242
IMGT
EMBL AC009532 AF081249 AF081250 AK296336 AK300358 AK304702 BC117127 CH471064 DA857260
GenPept AAD25922 AAD25923 AAI17128 BAH12320 BAH13268 BAH14239 EAW68559 EAW68560 EAW68561 EAW68562 EAW68563

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca