InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SMARCC1

Summary

InnateDB Gene

IDBG-31858.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SMARCC1

Gene Name

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1

Synonyms

BAF155; CRACC1; Rsc8; SRG3; SWI3

Species

Homo sapiens

Ensembl Gene

ENSG00000173473

Encoded Proteins

IDBP-31860

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1

IDBP-375399

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and contains a predicted leucine zipper motif typical of many transcription factors. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:47585272-47782106

Strand

Reverse strand

Band

p21.31

Transcripts

ENST00000254480	ENSP00000254480
ENST00000425518
ENST00000454240	ENSP00000414266
ENST00000492896
ENST00000483847
ENST00000462198
ENST00000485737
ENST00000485833

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 143 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.

Experimentally validated
Total	143 [view]
Protein-Protein	132 [view]
Protein-DNA	8 [view]
Protein-RNA	1 [view]
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	25 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0031492	nucleosomal DNA binding
GO:0047485	protein N-terminus binding

Biological Process

GO:0006337	nucleosome disassembly
GO:0006338	chromatin remodeling
GO:0006351	transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007399	nervous system development
GO:0008286	insulin receptor signaling pathway
GO:0009887	organ morphogenesis
GO:0043044	ATP-dependent chromatin remodeling
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0000790	nuclear chromatin
GO:0001741	XY body
GO:0005622	intracellular
GO:0005634	nucleus
GO:0016514	SWI/SNF complex
GO:0043234	protein complex
GO:0071564	npBAF complex
GO:0071565	nBAF complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000032481

View Gene Order

ENSBTAG00000031567

Not yet available

Pathways

NETPATH

NetPath_2

AndrogenReceptor pathway

NetPath_9

TNFalpha pathway

REACTOME

REACT_172623

Chromatin organization pathway

REACT_228108

RMTs methylate histone arginines pathway

REACT_172633

Chromatin modifying enzymes pathway

KEGG

INOH

PID NCI

reg_gr_pathway

Glucocorticoid receptor regulatory network

ar_tf_pathway

Regulation of Androgen receptor activity

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.476179 Hs.605181 Hs.619293

RefSeq

NM_003074

HUGO

OMIM

CCDS

CCDS2758

HPRD

03435

IMGT

EMBL

GenPept

RNA Seq Atlas