Version 5.4
Homo sapiens Gene: TTC19
Summary
InnateDB Gene IDBG-31947.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TTC19
Gene Name tetratricopeptide repeat domain 19
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000011295
Encoded Proteins
IDBP-31949
tetratricopeptide repeat domain 19
IDBP-759580
IDBP-764142
IDBP-761225
IDBP-763254
IDBP-764262
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein with a tetratricopeptide repeat (TPR) domain containing several TPRs of about 34 aa each. These repeats are found in a variety of organisms including bacteria, fungi and plants, and are involved in a variety of functions including protein-protein interactions. This protein is embedded in the inner mitochondrial membrane and is involved in the formation of the mitochondrial respiratory chain III. It has also been suggested that this protein plays a role in cytokinesis. Mutations in this gene cause mitochondrial complex III deficiency. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:15999380-16045015
Strand Forward strand
Band p12
Transcripts
ENST00000261647 ENSP00000261647
ENST00000466729 ENSP00000466261
ENST00000475723 ENSP00000465754
ENST00000470399 ENSP00000465082
ENST00000497842
ENST00000481107
ENST00000465567
ENST00000470649 ENSP00000465627
ENST00000578103 ENSP00000468372
ENST00000583704
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 10 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0000910 cytokinesis
GO:0034551 mitochondrial respiratory chain complex III assembly
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005813 centrosome
GO:0030496 midbody
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000042298
View Gene Order
ENSBTAG00000013270
Not yet available
Cross-References
SwissProt
TrEMBL K7EJA1
UniProt Splice Variant
Entrez Gene 54902
UniGene Hs.462316
RefSeq NM_001271420 NM_017775
HUGO HGNC:26006
OMIM 613814
CCDS CCDS11174
HPRD 07899
IMGT
EMBL AC002553 AC006251
GenPept
RNA Seq Atlas 54902

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca