Version 5.4
Homo sapiens Gene: MANBA
Summary
InnateDB Gene IDBG-32051.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MANBA
Gene Name mannosidase, beta A, lysosomal
Synonyms MANB1
Species Homo sapiens
Ensembl Gene ENSG00000109323
Encoded Proteins
IDBP-32053
mannosidase, beta A, lysosomal
IDBP-483781
mannosidase, beta A, lysosomal
IDBP-479086
mannosidase, beta A, lysosomal
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the glycosyl hydrolase 2 family. The encoded protein localizes to the lysosome where it is the final exoglycosidase in the pathway for N-linked glycoprotein oligosaccharide catabolism. Mutations in this gene are associated with beta-mannosidosis, a lysosomal storage disease that has a wide spectrum of neurological involvement. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:102631488-102760994
Strand Reverse strand
Band q24
Transcripts
ENST00000226578 ENSP00000226578
ENST00000514430
ENST00000505239 ENSP00000427322
ENST00000508141
ENST00000506478
ENST00000511813 ENSP00000422001
ENST00000507358
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004567 beta-mannosidase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006464 cellular protein modification process
GO:0006516 glycoprotein catabolic process
GO:0046355 mannan catabolic process
Cellular Component
GO:0005764 lysosome
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028164
View Gene Order
ENSBTAG00000019761
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00511
Other glycan degradation pathway
hsa04142
Lysosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.480415 Hs.674762
RefSeq NM_005908
HUGO
OMIM
CCDS CCDS3658
HPRD 02008
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca