Version 5.4
Homo sapiens Gene: LRP12
Summary
InnateDB Gene IDBG-32075.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LRP12
Gene Name low density lipoprotein receptor-related protein 12
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000147650
Encoded Proteins
IDBP-32077
low density lipoprotein receptor-related protein 12
IDBP-374815
low density lipoprotein receptor-related protein 12
IDBP-480776
low density lipoprotein receptor-related protein 12
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the low-density lipoprotein receptor related protein family. The product of this gene is a transmembrane protein that is differentially expressed in many cancer cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:104489231-104589024
Strand Reverse strand
Band q22.3
Transcripts
ENST00000276654 ENSP00000276654
ENST00000424843 ENSP00000399148
ENST00000518375
ENST00000523007 ENSP00000429305
ENST00000522046
ENST00000520770
ENST00000519675
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005041 low-density lipoprotein receptor activity
GO:0005515 protein binding
Biological Process
GO:0006897 endocytosis
GO:0006898 receptor-mediated endocytosis
GO:0007165 signal transduction
GO:0040008 regulation of growth
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0005905 coated pit
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022305
View Gene Order
ENSBTAG00000011516
Not yet available
Pathways
NETPATH
REACTOME
REACT_24968
Retinoid metabolism and transport pathway
REACT_111102
Signal Transduction pathway
REACT_160102
Diseases associated with visual transduction pathway
REACT_160125
Visual phototransduction pathway
REACT_116125
Disease pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.600630 Hs.715867
RefSeq NM_001135703 NM_013437
HUGO
OMIM
CCDS CCDS47907 CCDS6303
HPRD 17447
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca