Version 5.4
Homo sapiens Protein: LRP12
Summary
InnateDB Protein IDBP-32077.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LRP12
Protein Name low density lipoprotein receptor-related protein 12
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000276654
InnateDB Gene IDBG-32075 (LRP12)
Protein Structure
UniProt Annotation
Function Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. May act as a tumor suppressor. {ECO:0000269PubMed:12809483}.
Subcellular Localization Membrane {ECO:0000269PubMed:12809483}; Single-pass type I membrane protein {ECO:0000269PubMed:12809483}. Membrane, coated pit {ECO:0000269PubMed:12809483}.
Disease Associations
Tissue Specificity Widely expressed in heart, skeletal muscle, brain, lung, placenta and pancreas, but not in tissues consisting of a large number of epithelial cells, such as liver and kidney. Expressed at very low levels in a number of tumor-derived cell lines. {ECO:0000269PubMed:9927190}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005041 low-density lipoprotein receptor activity
GO:0005515 protein binding
Biological Process
GO:0006897 endocytosis
GO:0006898 receptor-mediated endocytosis
GO:0007165 signal transduction
GO:0040008 regulation of growth
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0005905 coated pit
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000859 CUB domain
IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
PFAM PF00431
PF00057
PRINTS PR00261
PIRSF
SMART SM00042
SM00192
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y561
PhosphoSite PhosphoSite-Q9Y561
TrEMBL E5RIW8
UniProt Splice Variant
Entrez Gene 29967
UniGene Hs.715867
RefSeq NP_038465
HUGO HGNC:31708
OMIM
CCDS CCDS6303
HPRD 17447
IMGT
EMBL AC087370 AC090827 AF166350 AK126348 AK289752 AK299374 AP002847 BC032109 CH471060
GenPept AAD44360 AAH32109 BAF82441 BAG54310 BAG61364 EAW91897

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca