Version 5.4
Homo sapiens Gene: PIGL
Summary
InnateDB Gene IDBG-32086.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PIGL
Gene Name phosphatidylinositol glycan anchor biosynthesis, class L
Synonyms CHIME
Species Homo sapiens
Ensembl Gene ENSG00000108474
Encoded Proteins
IDBP-32088
phosphatidylinositol glycan anchor biosynthesis, class L
IDBP-238731
phosphatidylinositol glycan anchor biosynthesis, class L
IDBP-761141
IDBP-809177
phosphatidylinositol glycan anchor biosynthesis, class L
IDBP-763466
IDBP-758636
IDBP-761781
IDBP-763201
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an enzyme that catalyzes the second step of glycosylphosphatidylinositol (GPI) biosynthesis, which is the de-N-acetylation of N-acetylglucosaminylphosphatidylinositol (GlcNAc-PI). Study of a similar rat enzyme suggests that this protein localizes to the endoplasmic reticulum. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:16217191-16351797
Strand Forward strand
Band p11.2
Transcripts
ENST00000225609 ENSP00000225609
ENST00000395844 ENSP00000379185
ENST00000431149
ENST00000414755
ENST00000498772
ENST00000470116 ENSP00000463754
ENST00000477745
ENST00000489009
ENST00000463810 ENSP00000485657
ENST00000488375
ENST00000596678 ENSP00000470064
ENST00000580201
ENST00000585034 ENSP00000464424
ENST00000581006 ENSP00000462432
ENST00000584797 ENSP00000463540
ENST00000607144
ENST00000613719
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0000225 N-acetylglucosaminylphosphatidylinositol deacetylase activity
Biological Process
GO:0006501 C-terminal protein lipidation
GO:0006506 GPI anchor biosynthetic process
GO:0016254 preassembly of GPI anchor in ER membrane
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000014245
View Gene Order
ENSBTAG00000013273
Not yet available
Pathways
NETPATH
REACTOME
REACT_952
Synthesis of glycosylphosphatidylinositol (GPI) pathway
REACT_1853
Post-translational modification: synthesis of GPI-anchored proteins pathway
REACT_22161
Post-translational protein modification pathway
REACT_17015
Metabolism of proteins pathway
KEGG
hsa00563
Glycosylphosphatidylinositol(GPI)-anchor biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL M0QYT4
UniProt Splice Variant
Entrez Gene 9487
UniGene
RefSeq NM_004278 XM_006721596
HUGO HGNC:8966
OMIM 605947
CCDS CCDS11176
HPRD 12071
IMGT
EMBL AC005971
GenPept
RNA Seq Atlas 9487

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca