Version 5.4
Homo sapiens Gene: MT3
Summary
InnateDB Gene IDBG-32105.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MT3
Gene Name metallothionein 3
Synonyms GIF; GIFB; GRIF; ZnMT3
Species Homo sapiens
Ensembl Gene ENSG00000087250
Encoded Proteins
IDBP-32107
metallothionein 3
IDBP-745243
IDBP-748177
IDBP-747760
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 16:56589074-56591088
Strand Forward strand
Band q13
Transcripts
ENST00000200691 ENSP00000200691
ENST00000570176 ENSP00000457164
ENST00000566576
ENST00000566451
ENST00000565838 ENSP00000455980
ENST00000561640 ENSP00000455353
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 3 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005507 copper ion binding
GO:0005515 protein binding
GO:0008144 drug binding
GO:0008270 zinc ion binding
GO:0016209 antioxidant activity
GO:0030295 protein kinase activator activity
GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0046870 cadmium ion binding
GO:0046872 metal ion binding
Biological Process
GO:0000060 protein import into nucleus, translocation
GO:0001666 response to hypoxia
GO:0001934 positive regulation of protein phosphorylation
GO:0006112 energy reserve metabolic process
GO:0006707 cholesterol catabolic process
GO:0006829 zinc ion transport
GO:0006875 cellular metal ion homeostasis
GO:0006882 cellular zinc ion homeostasis
GO:0006979 response to oxidative stress
GO:0008283 cell proliferation
GO:0010507 negative regulation of autophagy
GO:0010628 positive regulation of gene expression
GO:0010940 positive regulation of necrotic cell death
GO:0010942 positive regulation of cell death
GO:0014002 astrocyte development
GO:0016570 histone modification
GO:0019430 removal of superoxide radicals
GO:0030308 negative regulation of cell growth
GO:0030517 negative regulation of axon extension
GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0032095 regulation of response to food
GO:0032148 activation of protein kinase B activity
GO:0033210 leptin-mediated signaling pathway
GO:0034599 cellular response to oxidative stress
GO:0035690 cellular response to drug
GO:0036091 positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress
GO:0043066 negative regulation of apoptotic process
GO:0043085 positive regulation of catalytic activity
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043491 protein kinase B signaling
GO:0043524 negative regulation of neuron apoptotic process
GO:0044242 cellular lipid catabolic process
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0050768 negative regulation of neurogenesis
GO:0050821 protein stabilization
GO:0051354 negative regulation of oxidoreductase activity
GO:0055069 zinc ion homeostasis
GO:0055073 cadmium ion homeostasis
GO:0060049 regulation of protein glycosylation
GO:0060547 negative regulation of necrotic cell death
GO:0070371 ERK1 and ERK2 cascade
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071276 cellular response to cadmium ion
GO:0071456 cellular response to hypoxia
GO:0071732 cellular response to nitric oxide
GO:0097214 positive regulation of lysosomal membrane permeability
GO:2000117 negative regulation of cysteine-type endopeptidase activity
GO:2000376 positive regulation of oxygen metabolic process
GO:2000378 negative regulation of reactive oxygen species metabolic process
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0008021 synaptic vesicle
GO:0016234 inclusion body
GO:0048471 perinuclear region of cytoplasm
Orthologs
No orthologs found for this gene
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_005954
HUGO
OMIM
CCDS CCDS10762
HPRD 00752
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca