InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MT3

Summary

InnateDB Protein

IDBP-32107.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MT3

Protein Name

metallothionein 3

Synonyms

GIF; GIFB; GRIF; ZnMT3;

Species

Homo sapiens

Ensembl Protein

ENSP00000200691

InnateDB Gene

IDBG-32105 (MT3)

Protein Structure

UniProt Annotation

Function

Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium. Inhibits survival and neurite formation of cortical neurons in vitro.

Subcellular Localization

Disease Associations

Tissue Specificity

Abundant in a subset of astrocytes in the normal human brain, but greatly reduced in the Alzheimer disease (AD) brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	3 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005507	copper ion binding
GO:0005515	protein binding
GO:0008144	drug binding
GO:0008270	zinc ion binding
GO:0016209	antioxidant activity
GO:0030295	protein kinase activator activity
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0046870	cadmium ion binding
GO:0046872	metal ion binding

Biological Process

GO:0000060	protein import into nucleus, translocation
GO:0001666	response to hypoxia
GO:0001934	positive regulation of protein phosphorylation
GO:0006112	energy reserve metabolic process
GO:0006707	cholesterol catabolic process
GO:0006829	zinc ion transport
GO:0006875	cellular metal ion homeostasis
GO:0006882	cellular zinc ion homeostasis
GO:0006979	response to oxidative stress
GO:0008283	cell proliferation
GO:0010507	negative regulation of autophagy
GO:0010628	positive regulation of gene expression
GO:0010940	positive regulation of necrotic cell death
GO:0010942	positive regulation of cell death
GO:0014002	astrocyte development
GO:0016570	histone modification
GO:0019430	removal of superoxide radicals
GO:0030308	negative regulation of cell growth
GO:0030517	negative regulation of axon extension
GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0032095	regulation of response to food
GO:0032148	activation of protein kinase B activity
GO:0033210	leptin-mediated signaling pathway
GO:0034599	cellular response to oxidative stress
GO:0035690	cellular response to drug
GO:0036091	positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress
GO:0043066	negative regulation of apoptotic process
GO:0043085	positive regulation of catalytic activity
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043491	protein kinase B signaling
GO:0043524	negative regulation of neuron apoptotic process
GO:0044242	cellular lipid catabolic process
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0050768	negative regulation of neurogenesis
GO:0050821	protein stabilization
GO:0051354	negative regulation of oxidoreductase activity
GO:0055069	zinc ion homeostasis
GO:0055073	cadmium ion homeostasis
GO:0060049	regulation of protein glycosylation
GO:0060547	negative regulation of necrotic cell death
GO:0070371	ERK1 and ERK2 cascade
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0071276	cellular response to cadmium ion
GO:0071456	cellular response to hypoxia
GO:0071732	cellular response to nitric oxide
GO:0097214	positive regulation of lysosomal membrane permeability
GO:2000117	negative regulation of cysteine-type endopeptidase activity
GO:2000376	positive regulation of oxygen metabolic process
GO:2000378	negative regulation of reactive oxygen species metabolic process