InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: EPHB4

Summary

InnateDB Gene

IDBG-32108.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EPHB4

Gene Name

EPH receptor B4

Synonyms

HTK; MYK1; TYRO11

Species

Homo sapiens

Ensembl Gene

ENSG00000196411

Encoded Proteins

IDBP-32110

EPH receptor B4

IDBP-32112

EPH receptor B4

IDBP-808495

EPH receptor B4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene binds to ephrin-B2 and plays an essential role in vascular development. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:100802565-100827521

Strand

Reverse strand

Band

q22.1

Transcripts

ENST00000358173	ENSP00000350896
ENST00000360620	ENSP00000353833
ENST00000487222
ENST00000492403
ENST00000478459
ENST00000467515
ENST00000477446
ENST00000489808
ENST00000492878
ENST00000616502	ENSP00000482702

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	4 [view]
Protein-DNA	5 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004714	transmembrane receptor protein tyrosine kinase activity
GO:0005003	ephrin receptor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0001525	angiogenesis
GO:0002042	cell migration involved in sprouting angiogenesis
GO:0003007	heart morphogenesis
GO:0006468	protein phosphorylation
GO:0007155	cell adhesion
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0046777	protein autophosphorylation
GO:0048013	ephrin receptor signaling pathway