InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TRPV2

Summary

InnateDB Gene

IDBG-32212.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRPV2

Gene Name

transient receptor potential cation channel, subfamily V, member 2

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000187688

Encoded Proteins

IDBP-32214

transient receptor potential cation channel, subfamily V, member 2

IDBP-370349

transient receptor potential cation channel, subfamily V, member 2

IDBP-757947

IDBP-764886

IDBP-761254

IDBP-760105

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 20118928

TRPV2 has fundamental importance in innate immunity by participating in macrophage particle binding and early phagocytosis.

Entrez Gene

Summary

This gene encodes an ion channel that is activated by high temperatures above 52 degrees Celsius. The protein may be involved in transduction of high-temperature heat responses in sensory ganglia. It is thought that in other tissues the channel may be activated by stimuli other than heat. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:16415542-16437003

Strand

Forward strand

Band

p11.2

Transcripts

ENST00000338560	ENSP00000342222
ENST00000455666	ENSP00000390014
ENST00000475513
ENST00000493434
ENST00000580788	ENSP00000466130
ENST00000577865	ENSP00000467593
ENST00000583241
ENST00000581560	ENSP00000465609
ENST00000577277	ENSP00000464850

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005261	cation channel activity
GO:0005262	calcium channel activity
GO:0005515	protein binding
GO:0015075	ion transmembrane transporter activity

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0007600	sensory perception
GO:0009266	response to temperature stimulus
GO:0009408	response to heat
GO:0034220	ion transmembrane transport
GO:0045087	innate immune response (InnateDB)
GO:0045773	positive regulation of axon extension
GO:0055085	transmembrane transport
GO:0070588	calcium ion transmembrane transport
GO:0090280	positive regulation of calcium ion import

Cellular Component

GO:0005622	intracellular
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009986	cell surface
GO:0012505	endomembrane system
GO:0016021	integral component of membrane
GO:0030424	axon
GO:0032584	growth cone membrane
GO:0042470	melanosome
GO:0044295	axonal growth cone
GO:0044297	cell body

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000018507

View Gene Order

ENSBTAG00000003014

Not yet available

Pathways

NETPATH

REACTOME

REACT_160189

Stimuli-sensing channels pathway

REACT_15518

Transmembrane transport of small molecules pathway

REACT_25300

Ion channel transport pathway

REACT_169333

TRP channels pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_016113 XM_005256676 XM_005256678 XM_006721541 XM_006721543

HUGO

OMIM

CCDS

CCDS32576

HPRD

05980

IMGT

EMBL

GenPept

RNA Seq Atlas