Version 5.4
Homo sapiens Gene: TRIP6
Summary
InnateDB Gene IDBG-32241.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRIP6
Gene Name thyroid hormone receptor interactor 6
Synonyms OIP-1; OIP1; TRIP-6; TRIP6i2; ZRP-1
Species Homo sapiens
Ensembl Gene ENSG00000087077
Encoded Proteins
IDBP-32243
thyroid hormone receptor interactor 6
IDBP-383963
thyroid hormone receptor interactor 6
IDBP-383964
thyroid hormone receptor interactor 6
IDBP-383971
thyroid hormone receptor interactor 6
IDBP-811652
thyroid hormone receptor interactor 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the zyxin family and encodes a protein with three LIM zinc-binding domains. This protein localizes to focal adhesion sites and along actin stress fibers. Recruitment of this protein to the plasma membrane occurs in a lysophosphatidic acid (LPA)-dependent manner and it regulates LPA-induced cell migration. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:100867138-100873454
Strand Forward strand
Band q22.1
Transcripts
ENST00000200457 ENSP00000200457
ENST00000417475 ENSP00000413817
ENST00000437505 ENSP00000410736
ENST00000429658 ENSP00000389194
ENST00000496260
ENST00000476870
ENST00000463125
ENST00000488670
ENST00000619988 ENSP00000479865
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 123 experimentally validated interaction(s) in this database.
Experimentally validated
Total 126 [view]
Protein-Protein 124 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005149 interleukin-1 receptor binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0019900 kinase binding
GO:0044822 poly(A) RNA binding
GO:0046966 thyroid hormone receptor binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0008588 release of cytoplasmic sequestered NF-kappaB
GO:0030335 positive regulation of cell migration
GO:0048041 focal adhesion assembly
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0045323 interleukin-1 receptor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000023348
View Gene Order
ENSBTAG00000024772
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
KEGG
hsa04621
NOD-like receptor signaling pathway pathway
INOH
PID NCI
lysophospholipid_pathway
LPA receptor mediated events
ap1_pathway
AP-1 transcription factor network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_003302
HUGO
OMIM
CCDS CCDS5708
HPRD 04242
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca