Version 5.4
Mus musculus Gene: Trip6
Summary
InnateDB Gene IDBG-204924.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Trip6
Gene Name thyroid hormone receptor interactor 6
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000023348
Encoded Proteins
IDBP-204926
thyroid hormone receptor interactor 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000087077:
This gene is a member of the zyxin family and encodes a protein with three LIM zinc-binding domains. This protein localizes to focal adhesion sites and along actin stress fibers. Recruitment of this protein to the plasma membrane occurs in a lysophosphatidic acid (LPA)-dependent manner and it regulates LPA-induced cell migration. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:137309899-137314241
Strand Reverse strand
Band G2
Transcripts
ENSMUST00000024119 ENSMUSP00000024119
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 74 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 74 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005149 interleukin-1 receptor binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0019900 kinase binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007155 cell adhesion
GO:0008588 release of cytoplasmic sequestered NF-kappaB
GO:0030335 positive regulation of cell migration
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0045323 interleukin-1 receptor complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000087077
View Gene Order
ENSBTAG00000024772
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04621
NOD-like receptor signaling pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
KEGG
hsa04621
NOD-like receptor signaling pathway pathway
INOH
PID NCI
lysophospholipid_pathway
LPA receptor mediated events
ap1_pathway
AP-1 transcription factor network
Cross-References
SwissProt Q9Z1Y4
TrEMBL B2RS30
UniProt Splice Variant
Entrez Gene 22051
UniGene Mm.27063
RefSeq NM_011639
OMIM
CCDS CCDS19765
HPRD
IMGT
MGI ID MGI:1343458
MGI Symbol Trip6
EMBL AF097511 AF116823 AF312033 AK010435 AK159387 BC138685 BC138686 CH466529
GenPept AAC72380 AAD45984 AAI38686 AAI38687 AAK28821 BAB26937 BAE35042 EDL19278
RNA Seq Atlas 22051

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca