Version 5.4
Homo sapiens Gene: EDIL3
Summary
InnateDB Gene IDBG-32547.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EDIL3
Gene Name EGF-like repeats and discoidin I-like domains 3
Synonyms DEL1
Species Homo sapiens
Ensembl Gene ENSG00000164176
Encoded Proteins
IDBP-32549
EGF-like repeats and discoidin I-like domains 3
IDBP-32553
EGF-like repeats and discoidin I-like domains 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 22447028
The leukocyte integrin antagonist (EDIL3) Del-1 inhibits IL-17-mediated inflammatory bone loss. (Demonstrated in mice)
InnateDB Annotation from Orthologs
Summary
PMID 22447028
[Mus musculus] The leukocyte integrin antagonist (Edil3) Del-1 inhibits IL-17-mediated inflammatory bone loss.
Entrez Gene
Summary The protein encoded by this gene is an integrin ligand. It plays an important role in mediating angiogenesis and may be important in vessel wall remodeling and development. It also influences endothelial cell behavior. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:83940554-84384793
Strand Reverse strand
Band q14.3
Transcripts
ENST00000380138 ENSP00000369483
ENST00000296591 ENSP00000296591
ENST00000510271
ENST00000507663
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005178 integrin binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
Biological Process
GO:0007155 cell adhesion
GO:0007275 multicellular organismal development
GO:0010811 positive regulation of cell-substrate adhesion
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000034488
View Gene Order
ENSBTAG00000044033
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
avb3_integrin_pathway
Integrins in angiogenesis
integrin3_pathway
Beta3 integrin cell surface interactions
integrin5_pathway
Beta5 beta6 beta7 and beta8 integrin cell surface interactions
Cross-References
SwissProt O43854
TrEMBL
UniProt Splice Variant
Entrez Gene 10085
UniGene Hs.482730 Hs.613643 Hs.712860
RefSeq NM_001278642 NM_005711
HUGO HGNC:3173
OMIM 606018
CCDS CCDS4062 CCDS64195
HPRD
IMGT
EMBL AK312858 BC030828 BC053656 CH471084 U70312 U70313
GenPept AAC02648 AAC02649 AAH30828 AAH53656 BAG35710 EAW95917 EAW95918
RNA Seq Atlas 10085

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca